Barrier method as an effective strategy for the prevention and treatment of seasonal allergic rhinitis

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

To alleviate the symptoms of seasonal allergic rhinitis (SAR), along with the use of drugs, it is recommended to use medicinal agents that create a mechanical barrier that prevents pollen from getting on nasal mucosa and, consequently, the development of allergic reaction. Barrier methods are especially important in SAR treatment for pregnant females, children and elderly persons, since the side effects of many drugs limit their use in these groups of patients. Spray with microdispersed cellulose powder provides additional barrier protection of the nasal mucosa. Current article describes the mechanism of action of this medical device, and presents clinical observations from real practice confirming its efficacy and safety. Using of microdispersed cellulose powder helps to control SAR symptoms and reduce the amount of necessary pharmacotherapy.

Full Text

Restricted Access

About the authors

Ekaterina A. Orlova

Penza Institute for Advanced Medical Studies – branch of the Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia; Penza State University

Author for correspondence.
Email: lisaorl@yandex.ru
ORCID iD: 0000-0002-3902-2018
SPIN-code: 1700-4848

MD, Dr. Sci. (Medicine), associate professor, head of the Department of allergology and immunology with a course in dermatovenereology and cosmetology, professor of the Department of general and clinical pharmacology

Russian Federation, Penza; Penza

Yulia A. Kandrashkina

Penza Institute for Advanced Medical Studies – branch of the Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia; Penza State University

Email: novikova10l@mail.ru
ORCID iD: 0000-0002-5537-5729
SPIN-code: 3543-6165

MD, PhD (Medicine), associate professor of the Department of allergology and immunology with a course in dermatovenereology and cosmetology, associate professor of the Department of obstetrics and gynecology

Russian Federation, Penza; Penza

Elena M. Kostina

Penza Institute for Advanced Medical Studies – branch of the Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia

Email: elmihkostina@yandex.ru
ORCID iD: 0000-0003-1797-8040
SPIN-code: 2111-8827

MD, Dr. Sci. (Medicine), associate professor, professor of the Department of allergology and immunology with a course in dermatovenereology and cosmetology

Russian Federation, Penza

Alina A. Turovskaya

Penza Institute for Advanced Medical Studies – branch of the Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia

Email: alinaziboreva@yandex.ru
ORCID iD: 0000-0002-5138-808X
SPIN-code: 6211-7631

MD, assistant at the Department of allergology and immunology with a course in dermatovenereology and cosmetology

Russian Federation, Penza

References

  1. Клинические рекомендации. Аллергический ринит. Российская ассоциация аллергологов и клинических иммунологов, Союз педиатров России, Национальная медицинская ассоциация оториноларингологов. 2024. ID: 261_2. Доступ: https://cr.minzdrav.gov.ru/preview-cr/261_2 (дата обращения – 28.03.2025). [Clinical guidelines. Allergic rhinitis. Russian Association of Allergists and Clinical Immunologists, Union of Pediatricians of Russia, National Medical Association of Otorhinolaryngologists. Rubricator of clinical guidelines of the Ministry of Healthcare of Russia. 2020. ID: 62_2. URL: https://cr.minzdrav.gov.ru/preview-cr/62_2 (date of access – 28.03.2025) (In Russ.)].
  2. Климов А.В., Салахутдинова З.В., Пронина Н.А., Кузнецов Г.А. Дифференциальная диагностика эндотипов аллергического ринита. Сибирский журнал клинической и экспериментальной медицины. 2021;36(2):92–97. [Klimov AV, Salahutdinova ZV, Pronina NA, Kuznetsov GA. Differentiating the endotypes in allergic rhinitis. Sibirskiy zhurnal klinicheskoy i eksperimentalnoy meditsiny = The Siberian Journal of Clinical and Experimental Medicine. 2021;36(2):92–97 (In Russ.)]. EDN: XXGVKO. https://doi.org/10.29001/2073-8552-2021-36-2-92-97
  3. Балаболкин И.И. Поллиноз у детей и подростков: современные аспекты патогенеза и тенденции в терапии. Аллергология и иммунология в педиатрии. 2020;(3):6–14. [Balabolkin II. Pollinosis in children and adolescents: Modern aspects of pathogenesis and tendencies in therapy. Allergologiya i immunologiya v pediatrii = Allergology and Immunology in Pediatrics. 2020;(3):6–14 (In Russ.)]. EDN: FHNCGC. https://doi.org/10.24411/2500-1175-2020-10007
  4. Орлова Е.А. Современные принципы аллерген-специфической иммунотерапии. Руководство для врачей. М.: ГЭОТАР-Медиа. 2023; 256 с. [Orlova EA. Modern principles of allergen-specific immunotherapy. A guide for doctors. Moscow: GEOTAR-Media. 2023; 256 pp. (In Russ.)]. ISBN: 978-5-9704-7781-6. EDN: SWEXUZ. https://doi.org/10.33029/9704-7781-6-OEA-2023-1-256
  5. Ильина Н.И., Польнер С.А. Круглогодичный аллергический ринит. Consilium Medicum. 2001;3(8):384–393. [Ilyna NI, Polner SA. Perennial allergic rhinitis. Consilium Medicum. 2001;3(8):384–393 (In Russ.)]. EDN: WZJQRP.
  6. Горячкина Л.А., Передкова Е.В., Астафьева Н.Г. Поллинозы. В кн.: Клиническая аллергология и иммунология. Руководство для практикующих врачей. Под ред. Л.А. Горячкиной, К.П. Кашкина. М.: Миклош 2009: с. 351–362. [Goryachkina LA, Peredkova EV, Astafieva NG. Pollinosis. In the book: Clinical allergology and immunology. Handbook for practicing physicians. Ed. by Goryachkina L.A., Kashkina K.P. Moscow: Miklosh. 2009: pp. 351–362 (In Russ.)]. ISBN: 978-5-91746-002-4.
  7. Себекина О.В., Передкова Е.В., Ненашева Н.М. Снижение медикаментозной нагрузки при аллергическом рините. Эффективная фармакотерапия. 2020;16(8):24–30. [Sebekina OV, Peredkova EV, Nenasheva NM. Reducing the drug load in allergic rhinitis. Effektivnaya farmakoterapiya = Effective Pharmacotherapy. 2020;16(8):24–30 (In Russ.)]. EDN: ICZKQE. https://doi.org/10.33978/2307-3586-2020-16-8-24-30
  8. Орлова Е.А., Костина Е.М., Трушина Е.Ю. Роль барьерного метода в терапии сезонного аллергического ринита. Практическая аллергология. 2021;(2):80–84. [Orlova EA, Kostina EM, Trushina EYu. The role of the barrier method in the treatment of seasonal allergic rhinitis. Prakticheskaya allergologiya = Practical Allergology. 2021;(2):80–84 (In Russ.)]. EDN: YRMODL. https://doi.org/10.46393/2712-9667_2021_2_80_84
  9. Орлова Е.А., Костина Е.М., Трушина Е.Ю., Кандрашкина Ю.А. Назаваль®: возможность использования в лечении и профилактике аллергического ринита у беременных. Практическая аллергология. 2021;(1):17–23. [Orlova EA, Kostina EM, Trushina EYu, Kandrashkina YuA. Nazaval®: The possibility of using in the treatment and prevention of allergic rhinitis in pregnant women. Practicheskaya allergologiya = Practical Allergology. 2021;(1):17–23 (In Russ.)]. EDN: DBLROH. https://doi.org/10.46393/2712-9667_2021_1_17-23
  10. Incaudo GA. Diagnosis and treatment of allergic rhinitis and sinusitis during pregnancy and lactation. Clin Rev AllergyImmunol. 2004;27(2):159–77. PMID: 15576899. https://doi.org/10.1385/CRIAI:27:2:159
  11. Saito S, Nakashima A, Shima T, Ito M. Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy. Am J Reprod Immunol. 2010;63(6):601–10. PMID: 20455873. https://doi.org/10.1111/j.1600-0897.2010.00852.x
  12. Лопатин А.С. Диагностика и лечение ринита и риносинусита у беременных. Российский аллергологический журнал. 2006;(1):6–12. [Lopatin AS. Diagnostics and treatment of rhinitis and rhinosinusitis in pregnant women. Rossiyskiy allergologicheskiy zhurnal = Russian Journal of Allergy. 2006;(1):6–12 (In Russ.)].
  13. Лусс Л.В. Аллергия и беременность. Лекция для врачей. Доктор. Pу. 2011;(3):36–43. [Luss LV. Allergy and pregnancy. Lecture for doctors. Doctor. Pu. 2011;(3):36–43 (In Russ.)]. EDN: OPGBUD.
  14. Балаболкин И.И., Ксензова Л.Д., Беляева Е.Д. Поллинозы у детей и подростков. Педиатрическая фармакология. 2007;4(2):66–70. [Balabolkin II, Ksenzova LD, Belyaeva LD. Pollinoses in children and adolescents. Pediatricheskaya farmakologiya= Pediatric Pharmacology. 2007;4(2):66–70 (In Russ.)]. EDN: JUCHNX.
  15. Сапова К.И., Рязанцев С.В. Особенности лечения круглогодичного аллергического ринита у пациентов старшей возрастной группы. Медицинский совет. 2018;(20):107–110. [Sapova KI, Ryazantsev SV. Characteristics of the treatment of perennial allergic rhinitis in patients of the older age group. Meditsinskiy sovet = Medical Council. 2018;(20):107–110 (In Russ.)]. EDN: YNGRSP. https://doi.org/10.21518/2079-701X-2018-20-107-110
  16. Лусс Л.В., Шартанова Н.В., Назарова Е.В. Аллергический и неаллергический ринит: эффективность барьерных методов. Эффективная фармакотерапия. 2018;(17):10–16. [Luss LV, Shartanova NV, Nazarova EV. Allergic and non-allergic rhinitis: The effectiveness of barrier methods. Effektivnaya farmakoterapiya = Effective Pharmacotherapy. 2018;(17):10–16. (In Russ.)]. EDN: XQYQRV.
  17. [Li YY, J X, Li PZ, Wan LL. Clinical effects assessment of nasal cellulose powder on allergic rhinitis. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi = Journal of Clinical Otorhinolaryngology Head and Neck Surgery. 2017;31(2):138–41 (In Chinese)]. PMID: 29871205. https://doi.org/10.13201/j.issn.1001-1781.2017.02.014
  18. Popov TA, Aberg N, Emberlin J, Josling P, Ilyina NI, Nikitin NP, Church M. Methyl-cellulose powder for prevention and management of nasal symptoms. Expert Review of Respiratory Medicine. 2017;11(11):885–92. PMID: 28862062. https://doi.org/10.1080/17476348.2017.1375408
  19. Bouic PJD. A review of the efficacy and safety of NasalezeTM in the prevention and management of allergic rhinitis. TheOpenAllergyJournal. 2008;1(1):4. https://doi.org/10.2174/1874838400801010001
  20. Захаржевская Т.В., Сидоренко И.В., Трескунов В.К., Караулов А.В. Возможности использования нового назального спрея Назаваль® в лечении и профилактике аллергического ринита. Российский аллергологический журнал. 2009;(4):82–86. [Zaharzhevskaya TV, Sidorenko IV, Treskunov VK, Karaulov AV. Possibilities of using the new nasal spray Nazaval® in the treatment and prevention of allergic rhinitis. Rossiyskiy allergologicheskiy zhurnal = Russian Journal of Allergy. 2009;(4):82–86 (In Russ.)]. EDN: KZBPDF.
  21. Назаваль. Инструкция по применению медицинского изделия – средства (фильтра) барьерного отоларингологического. Регистрационный номер: ФСЗ 2008/02844 от 28.03.2018. Доступ: https://databaseprodotti.zambon.com/sites/default/files/product_downloads/D161503.pdf (дата обращения – 28.03.2025). [Nazaval. Instruction for use of a medical device – a barrier otolaryngological device (filter). Registration certificate: ФСЗ 2008/02844 dated 03/28/2018. URL: https://databaseprodotti.zambon.com/sites/default/files/product_downloads/D161503.pdf (date of access – 28.03.2025) (In Russ.)].
  22. Василевский И.В. Что важно знать при лечении аллергии во время беременности. Медицинские знания. 2019;(5):3–11. [Vasilevskiy IV. What is important to know when treating allergies during pregnancy. Meditsinskie znaniya = Medical Knowledge. 2019;(5):3–11 (In Russ.)].
  23. Себекина О.В., Ненашева Н.М. Современные барьерные методы для профилактики и лечения аллергического ринита. Медицинский оппонент. 2019;2(6):37–47. [Sebekina OV, Nenasheva NM. Modern barrier methods for the prevention and treatment of allergic rhinitis. Meditsinskiy opponent = Medical Opponent. 2019;2(6):37–47 (In Russ.)]. EDN: YOTBNG.
  24. Ревякина В.А. Немедикаментозные методы защиты у детей с поллинозом. Эффективная фармакотерапия. 2013;1(20):16–20. [Revyakina VA. Non-drug methods of protection in children with hay fever. Effektivnaya farmakoterapiya = Effective Pharmacotherapy. 2013;1(20):16–20 (In Russ.)]. EDN: SAKKXX.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2025 Bionika Media