Possibilities of fixed combination of nitrendipine and enalapril in the treatment of arterial hypertension


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Abstract

Modern approaches to the therapy of arterial hypertension involve the use of a combination of antihypertensive drugs at the beginning of treatment. The combination of an angiotensin-converting enzyme inhibitor with a long-acting calcium channel blocker presents an alternative to widely used combinations with diuretics. According to the results of clinical studies, combination of enalapril with nitrendipine has proved to be a highly effective and safe, including in elderly patients. The combined use of these drugs increases the antihypertensive effect, while reducing the severity of the side effects of each component.

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About the authors

Galina A. Batishcheva

N.N. Burdenko Voronezh State medical university

MD, professor, head of the Department of clinical pharmacology

Olga A. Mubarakshina

N.N. Burdenko Voronezh State medical university

Email: mubarakshina@mail.ru
PhD, assistant of the Department of clinical pharmacology

Marina N. Somova

N.N. Burdenko Voronezh State medical university

Email: somova_marina@inbox.ru
PhD, associate professor of the Department of clinical pharmacology

Anastasiya S. Yevstigneeva

N.N. Burdenko Voronezh State medical university

clinical intern of the Department of clinical pharmacology

References

  1. Ahluwalia M., Bangalore S. Management of hypertension in 2017: targets and therapies. Curr. Opin. Cardiol. 2017 Mar 24.
  2. Bhatt D.L., Steg P.G., Ohman E.M., Hirsch A.T., Ikeda Y., Mas J.L., Goto S., Liau C.S., Richard A.J., Röther J., Wilson P.W.; REACH Registry Investigators. International prevalence, recognition, and treatment of cardiovascular risk factors in outpatients with atherothrombosis. JAMA. 2006;295(2):180-9.
  3. Николаев Н.А. Инновационная антигипертензивная терапия в свете завершенных научных исследований. Рациональная фармакотерапия в кардиологии. 2009;2:89-97. [Nikolaev N.A. Innovative antihypertensive therapy in the light of the completed research. Rational pharmacotherapy in cardiology. 2009;2:89-97 (in Russ.)]
  4. Диагностика и лечение артериальной гипертонии. Клинические рекомендации. Министерство здравоохранения РФ. Москва, 2013. URL: http://www.gipertonik.ru/files/recommendation/Reco.mmendations_hypertension.docx. [Diagnosis and treatment of hypertension. Clinical guidelines. Ministry of Healthcare of the Russian Federation. Moscow, 2013 (in Russ.)]
  5. Рабочая группа по лечению артериальной гипертонии Европейского общества гипертонии (European Society of Hypertension, ESH) и Европейского общества кардиологов (European Society of Cardiology, ESC). Рекомендации по лечению артериальной гипертонии. ESH/ESC 2013. Российский кардиологический журнал. 2014; 1 (105):7-94. [Working group on the management of arterial hypertension of European Society of Hypertension and European Society of Cardiology. Recommendations for treatment of hypertension. ESH/ESC 2013. Russian journal of cardiology. 2014;1(105):7-94 (in Russ.)]
  6. Wald D.S., Law M., Morris J.K., Bestwick J.P., Wald N.J. Combination therapy versus monotherapy in reducing blood pressure: meta-analysis on 11 000 participants from 42 trials. Am. J. Med. 2009;122:290-300.
  7. Corrao G., Parodi A., Zambon A., Heiman F., Filippi A., Cricelli C., Merlino L., Mancia G. Reduced discontinuation of antihypertensive treatment by two-drug combination as first step. Evidence from daily life practice. J. Hypertens. 2010; 28:1584-90.
  8. Чукаева И.И. Комбинированная гипотензивная терапия: возможности полнодозовых комбинаций в достижении комплаентности. Consilium Medicum. 2012;14(10):126-30. [Chukaeva I.I. Combined antihypertensive therapy: opportunities of full-doze combinations in achieving compliance. Consilium Medicum. 2012;14(10):126-30 (in Russ.)]
  9. Карпов Ю.А., Сорокин Е.В. Новые лекарственные комбинации - новые возможности гипотензивной терапии. Атмосфера. Новости кардиологии. 2015;1:2-7. [Karpov Yu.A., Sorokin Ye.V. New drug combinations - new possibilities of antihypertensive therapy. Atmosphere. News of cardiology. 2015;1:2-7 (in Russ.)]
  10. Морозова Т.Е., Андрущишина Т.Б., Юдина И.Ю. Комбинированная фармакотерапия артериальной гипертонии. Обзор фиксированных комбинаций антигипертензивных препаратов. Системные гипертензии. 2016;3:58-63. [Morozova T.Ye., Andrushchishina T.B., Yudin I.Yu. Combined pharmacotherapy of arterial hypertension. Review of fixed combinations of antihypertensive drugs. Systemic hypertension. 2016;3:58-63 (in Russ.)]
  11. Nichols W.W., O'Rourke M.F. McDonald's blood flow in arteries: theoretic, experimental and clinical principles. 5th ed. London: Edward Arnold, 2005.
  12. Khan N.A., McAlister F.A., Lewanczuk R.Z., Touyz R.M., Padwal R., Rabkin S.W., Leiter L.A., Lebel M., Herbert C., Schiffrin E.L., Herman R.J., Hamet P., Fodor G., Carruthers G., Culleton B., DeChamplain J., Pylypchuk G., Logan A.G., Gledhill N., Petrella R., Campbell N.R., Arnold M., Moe G., Hill M.D., Jones C., Larochelle P., Ogilvie R.I., Tobe S., Houlden R., Burgess E., Feldman R.D. The 2005 Canadian Hypertension Education Program recommendations for the management of hypertension: part II: therapy. Can J Cardiol. 2005;21:657-72.
  13. Орлова Я.А. Новая фиксированная комбинация нитрендипина и эналаприла в помощь поликлиническому врачу. Consilium Medicum. 2014;16(10):11-6. [Orlova Ya.A. New fixed combination of nitrendipine and enalapril to help the outpatient doctor. Consilium Medicum. 2014;16(10):11-6 (in Russ.)]
  14. Крючкова О.Н., Ицкова Е.А., Лутай Ю.А., Турна Э.Ю. Современная фиксированная антигипертензивная терапия: эналаприл и нитрендипин. Ульяновский медико-биологический журнал. 2015;1:27-34. [Kruchkova O.N., Itskova Ye.A., Lutay Yu.A., Turna E.Yu. Contemporary fixed antihypertensive therapy: enalapril and nitrendipine. Ulyanovsk medico-biological journal. 2015;1:27-34 (in Russ.)]
  15. Roca-Cusachs A. et al. Grupo Espanol de Estudio de Enalapril/Nitrendipino. Hipertensiân. 2002;19 (Suppl. 2):175(abstr 85-T)
  16. de la Sierra A., Roca-Cusachs A., Redân J., Marin R., Luque M., de la Figuera M., Garcia-Garcia M., Falkon L.; CENIT Study Working Group. Effectiveness and tolerability of fixed-dose combination enalapril plus nitrendipine in hypertensive patients: results of the 3-month observational, postmarketing, multicentre, prospective CENIT study. Clin. Drug Investig. 2009;29(7):459-69.
  17. Thijs L., Richart T., de Leeuw P., Kuznetsova T., Grodzicki T., Kawecka-Jaszcz K., O'Brien E., Redón J., Birkenhäger W.H., Fagard R., Staessen J.A. Morbidity and mortality on combination versus monotherapy: a posthoc analysis of the Systolic Hypertension in Europe trial. J. Hypertens. 2010;28(4):865-74.
  18. Eber B., Weber T., Artmann А., Enayati S. Fixkombination Enalapril/Nitrendipin in der täglichen Praxis - Effektivität und Verträglichkeit bei 1.262 österreichischen Hypertonikern. Austrian J. Hypertens. 2007;11(2):22-5.
  19. Trenkwalder P. The Efficacy and Tolerability of an Antihypertensive Fixed Combination of Enalapril and Nitrendipine. Perfusion. 2004;7:394-9.

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