ETIOLOGY OF SEVERE ACUTE RESPIRATORY VIRAL INFECTION DURING THE EPIDEMIC SEASONS 2015-2020


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The aim of the study was to establish the contribution of separate etiological agents to the development of severe forms of acute respiratory viral infections (SARI) registered in hospital conditions depending on the age of patients during several consecutive epidemic seasons. Material and methods. A retrospective analysis of the etiology of SARI cases was carried out in 14 414 hospitalized patients included in the study on hospital surveillance of influenza in the 2015- 2020 seasons, for which a laboratory decoding of ARVI etiology was obtained. Results. The contribution of various influenza viruses to the development of SARI was determined, and the leading role of influenza A (H1N1) pdm09 viruses as a reason point for hospitalization in the intensive care unit (ICU) was shown. The role of viruses of non- influenza etiology in children’s morbidity has been demonstrated, including the importance of the respiratory syncytial virus as the leading pathogen in acute respiratory viral infections structure in young children, leading to the development of SARI with subsequent ICU hospitalization. In addition, the contribution of rhinovirus infection to the development of ARVI in patients of all age groups hospitalized with SARI of noninfluenza etiology was determined. Conclusion. Current study demonstrates the importance of continuing research in the field of hospital monitoring for influenza and other acute respiratory viral infections, especially in conditions of active circulation of the causative agent of new COViD-19 coronaviral infection.

Full Text

Restricted Access

About the authors

Daria M. Danilenko

A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia

Email: daria.danilenko@influenza.spb.ru
candidate of biological sciences, Deputy Director for scientific work, head of the Department of etiology and epidemiology 197376, St. Petersburg, 15/17 Professor Popov Str

Anna A. Sominina

A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia

Email: anna.sominina@influenza
MD, professor, head of the laboratory for the study of risk factors for influenza and acute respiratory viral infections, chief researcher 197376, St. Petersburg, 15/17 Professor Popov Str

Andrey B. Komissarov

A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia

Email: andrey.komissarov@influenza.spb.ru.com
head of the laboratory of molecular virology 197376, St. Petersburg, 15/17 Professor Popov Str

Maria M. Pisareva

A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia

Email: maria.pisareva@influenza.spb.ru
candidate of biological sciences, leading researcher of the laboratory of molecular virology 197376, St. Petersburg, 15/17 Professor Popov Str

Kirill A. Stolyarov

A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia

Email: kirill@influenza.spb.ru
leading programmer of the laboratory of epidemiology of influenza and acute respiratory disorders 197376, St. Petersburg, 15/17 Professor Popov Str

Tamila D. Musaeva

A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia

Email: tamila.musaeva@influenza.spb.ru
junior researcher of the laboratory of molecular virology 197376, St. Petersburg, 15/17 Professor Popov Str

Veronika Eder

A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia

Email: veronika.eder@influenza.spb.ru
senior researcher of the laboratory of molecular virology 197376, St. Petersburg, 15/17 Professor Popov Str

Mikhail I. Bakaev

A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia

Email: mibakaev18@gmail.com
junior researcher of the laboratory of molecular virology 197376, St. Petersburg, 15/17 Professor Popov Str

Ksenia S. Komissarova

A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia

Email: ksenia.komissarova@influenza.spb.ru
junior researcher of the laboratory of molecular virology 197376, St. Petersburg, 15/17 Professor Popov Str

Anna A. Ivanova

A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia

Email: anna.ivanova@influenza.spb.ru
junior researcher of the laboratory of molecular virology 197376, St. Petersburg, 15/17 Professor Popov Str

Artem V. Fadeev

A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia

Email: artem.fadeev@influenza.spb.ru
researcher of the laboratory of molecular virology 197376, St. Petersburg, 15/17 Professor Popov Str

Elizaveta A. Smorodintseva

A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia

Email: liza.smorodintseva@influenza.spb.ru
leading researcher of the laboratory of epidemiology of influenza and acute respiratory diseases 197376, St. Petersburg, 15/17 Professor Popov Str

Elena G. Rozhkova

A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia

Email: elena.rozhkova@influenza.spb.ru
PhD., leading researcher, Department of experimental and clinical research 197376, St. Petersburg, 15/17 Professor Popov Str

Dmitry A. Guzhov

A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia; S.P. Botkin Clinical Infectious Diseases Hospital

Email: dimas1992@list.ru
full-time postgraduate student; infectious disease physician 191024, St. Petersburg, 3 Mirgorodskaya Str

Evgeny V. Venev

A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia; S.P. Botkin Clinical Infectious Diseases Hospital

Email: imberbis@gmail.com
full-time postgraduate student, senior lecturer; infectious disease physician 197376, St. Petersburg, 15/17 Professor Popov Str

Elena A. Dondurey

A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia; N.F. Filatov Children's City Clinical Hospital No. 5; Health Committee of the Government of St. Petersburg

Email: elena.dondurei@influenza.spb.ru
senior researcher of the Department of respiratory viral infections in children; head of the Department - infectious disease doctor of the infectious boxed Department No. 10; Chief freelance specialist on infectious diseases in children 192289, St. Petersburg, 134 Bukharestskaya Str

Olga I. Afanasieva

A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia; St. Olga Children's City Hospital

Email: olga.afanasieva@influenza.spb.ru
MD, head of the Department of respiratory viral infections in children 194156, St. Petersburg, 2 Zemledeltcheskaya Str

Elena V. Obraztsova

A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia; N.F. Filatov Children's City Clinical Hospital No. 5

Email: elena.obraztsova@influenza.spb.ru
PhD, senior researcher of the Department of respiratory viral infections in children 192289, St. Petersburg, 134 Bukharestskaya Str

Veronika S. Timonina

A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia; St. Olga Children's City Hospital

neonatologist 194156, St. Petersburg, 2 Zemledeltcheskaya Str

Ekaterina G. Golovacheva

A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia; St. Olga Children's City Hospital

Email: golovacheva@influenza.spb.ru
PhD, senior researcher of the laboratory for development and testing of pharmaceutical agents 194156, St. Petersburg, 2 Zemledeltcheskaya Str

Olga G. Kurskaya

Federal Research Center for Fundamental and Translational Medicine

Email: kurskaya_og@mail.ru
PhD, senior researcher of the laboratory for development and testing of pharmaceutical agents 630117, Novosibirsk, 2 Timakova Str

Alexander M. Shestopalov

Federal Research Center for Fundamental and Translational Medicine

Email: shestopalov2@ngs.ru
doctor of biological sciences, professor, head of the Department of experimental modeling and pathogenesis of infectious diseases 630117, Novosibirsk, 2 Timakova Str

Alexander V. Alimov

Yekaterinburg Research Institute of Viral Infections of SSC VB «Vector» of Rospotrebnadzor

Email: alexalimov@yandex.ru
PhD, Director of Yekaterinburg Research Institute of Viral Infections 620030, Yekaterinburg, 23 Letnyja Str

Evgenia V. Lelenkova

Yekaterinburg Research Institute of Viral Infections of SSC VB «Vector» of Rospotrebnadzor

Email: e.lelenkova@inbox.ru
epidemiologist of Yekaterinburg Research Institute of Viral Infections 620030, Yekaterinburg, 23 Letnyja Str

Dmitry A. Lioznov

A.A. Smorodintsev Research Institute of Influenza of the Ministry of Healthcare of Russia; Acad. I.P. Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russia

Email: office@influenza.spb.ru
acting director; head of the Department of infectious diseases 197376, St. Petersburg, 15/17 Professor Popov Str

References

  1. Соминина А.А., Смородинцева Е.А., Столяров К.А., Мельникова А.А. Совершенствование системы надзора за гриппом в Российской Федерации: основные результаты сигнального надзора за гриппом и другими острыми респираторными вирусными инфекциями. Эпидемиология и вакцинопрофилактика. 2017; 1: 7-15. doi: https://doi.org/10.31631/2073-3046-2017-16-1-7-15.
  2. Govorkova E.A., Webster R.G. Combination chemotherapy for influenza. Viruses. 2010; 2(8): 1510-29. doi: 10.3390/v2081510.
  3. Hayden F.G. Advances in antivirals for non-influenza respiratory virus infections. Influenza Other Respir Viruses. 2013; 7 Suppl 3(Suppl 3): 36-43. doi: 10.1111/irv.12173.
  4. Ibrahim N.K. Epidemiologic surveillance for controlling Covid-19 pandemic: types, challenges and implications. J Infect Public Health. 2020; 13(11): 1630-38. doi: 10.1016/j.jiph.2020.07.019.
  5. Puig-Barbera J., Tormos A., Trushakova S. et al. GIHSN Group. The Global Influenza Hospital Surveillance Network (GIHSN): a new platform to describe the epidemiology of severe influenza. Influenza Other Respir Viruses. 2015; 9(6): 277-86. doi: 10.1111/irv.12335.
  6. El Guerche-Seblain C., Commaille-Chapus C., Morizet M. et al. The global influenza hospital surveillance network (GIHSN), a worldwide platform for timely generation of severe influenza epidemiological data. Revue d'Ėpidėmiologie et de Santė Publique. 2018; 66(5): S384-S385. doi: 10.1016/j.respe.2018.05.404.
  7. McBean A.M., Hebert P.L. New estimates of influenza-related pneumonia and influenza hospitalizations among the elderly. Int J Infect Dis. 2004; 8(4): 227-35. doi: 10.1016/j.ijid.2004.04.013.
  8. Kodama F., Nace D.A., Jump R.L.P. Respiratory Syncytial virus and other Noninfluenza respiratory viruses in older adults. Infect Dis Clin North Am. 2017; 31(4): 767-90. doi: 10.1016/j.idc.2017.07.006.
  9. Hyvarinen M.K., Kotaniemi-Syrjanen A., Reijonen T.M. et al. Lung function and bronchial hyper-responsiveness years after hospitalization for bronchiolitis. Acta Paediatr. 2007; 96(10): 1464-69. doi: 10.1111/j.1651-2227.2007.00458.x.
  10. Fica A., Dabanch J., Andrade W. et al. Clinical relevance of rhinovirus infections among adult hospitalized patients. Braz J Infect Dis. 2015; 19(2): 118-24. doi: 10.1016/j.bjid.2014.10.003.
  11. Pretorius M.A. Investigation of the association of Rhinovirus and Respiratory Syncytial Virus with severe acute respiratory illness in South Africa. 2016. Thesis. URL: https://reository.up.ac.za/handle/2263/53041 (date of access - 02.04.2021).

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2021 Bionika Media