Additional diagnostic markers of comorbid version of vibration disease combined with arterial hypertension
- Authors: Gorbunova A.M.1, Gerasimenko O.N.1, Shpagin I.S.1, Belyaeva T.M.2, Tolmacheva A.A.2, Maksimov V.N.1,3
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Affiliations:
- Novosibirsk State Medical University of the Ministry of Healthcare of Russia
- Semey Medical University of the Ministry of Healthcare of the Republic of Kazakhstan
- Research Institute of Therapy and Preventive Medicine – a branch of the Federal Research Center “Institute of Cytology and Genetics of the Siberian branch of the Russian Academy of Sciences”
- Issue: Vol 10, No 5 (2024)
- Pages: 68-78
- Section: ORIGINAL STUDIES
- URL: https://journals.eco-vector.com/2412-4036/article/view/635071
- DOI: https://doi.org/10.18565/therapy.2024.5.68-78
- ID: 635071
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Abstract
Vibration disease (VD) in combination with arterial hypertension (AH) today is one of the leading problems in therapeutic clinical practice and occupational medicine.
The aim: to study additional clinical-functional, nutritional-metabolic and molecular-genetic diagnostic markers of the comorbid variant of VD in combination with arterial hypertension.
Material and methods. A single-center, open, non-randomized, cross-sectional study was performed. All the participants were divided into four groups: 1st – patients with isolated VD (n = 104); 2nd – patients with arterial hypertension (n = 107); 3rg group – patients with comorbid model of VD + arterial hypertension (n = 101); 4th (control group) – conditionally healthy individuals working at the same enterprise without contact with vibration and not suffering from hypertension (n = 119).
Results. The following most significant changes were revealed in VB + AH group: an increase in the frequency of general and specific complaints, high body mass index values corresponding to obesity of the 2nd and 3rd degrees, decrease in active cell mass and phase angle, decrease of adipocytokine profile indexes, lower vitamin D levels comparatively to other groups (all p < 0.0001). It was found that the molecular picture of inflammation in case of VD combined with arterial hypertension differs significantly from that in case of isolated VD and case of isolated hypertension. When studying a group of patients with VD + arterial hypertension, it was found that the increased frequency of T/T rs4880 genotype of superoxide dismutase SOD2 gene appears to be a characteristic of oxidative stress.
Conclusion. Formation of VD, combined with arterial hypertension, occurs secondary to nutritional and metabolic disorders in association with clinical and functional parameters, changes in adipocytokine status, systemic inflammation, vitamin D levels, endothelial dysfunction and oxidative stress, as well as an increased frequency of detection of the polymorphic variant of T/T locus Ala 16 Val (rs4880) of the MnSOD (superoxide dismutase) gene.
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About the authors
Alena M. Gorbunova
Novosibirsk State Medical University of the Ministry of Healthcare of Russia
Author for correspondence.
Email: belyaeva-alena@list.ru
ORCID iD: 0000-0002-1593-3984
MD, postgraduate student, assistant, head of the educational unit of the Department of faculty therapy named after professor G.D. Zalessky of the Faculty of general medicine
Russian Federation, 630005, Novosibirsk, 71 Demyana Bednogo St.Oksana N. Gerasimenko
Novosibirsk State Medical University of the Ministry of Healthcare of Russia
Email: profgerasimenko@inbox.ru
ORCID iD: 0000-0002-9742-0479
MD, Dr. Sci. (Medicine), professor, head of the Department of faculty therapy named after professor G.D. Zalessky of the Faculty of general medicine
Russian Federation, 630005, Novosibirsk, 71 Demyana Bednogo St.Ilya S. Shpagin
Novosibirsk State Medical University of the Ministry of Healthcare of Russia
Email: Dr.ilya.shpagin@gmail.ru
MD, Dr. Sci. (Medicine), associate professor of the Department of hospital therapy and medical rehabilitation of the Faculty of pediatrics
Russian Federation, 630051, Novosibirsk, 21 Polzunova St.Tatyana M. Belyaeva
Semey Medical University of the Ministry of Healthcare of the Republic of Kazakhstan
Email: btm56@rambler.ru
ORCID iD: 0000-0002-2565-2393
MD, PhD (Medicine), associate professor of the Department of general medical practice
Kazakhstan, 071400, Semey, 103 Abaya St.Anastasia A. Tolmacheva
Semey Medical University of the Ministry of Healthcare of the Republic of Kazakhstan
Email: tolmacheva_nastena@mail.ru
ORCID iD: 0000-0003-1687-4100
MD, PhD (Medicine), assistant at the Department of faculty therapy named after professor G.D. Zalessky of the Faculty of general medicine
Kazakhstan, 071400, Semey, 103 Abaya St.Vladimir N. Maksimov
Novosibirsk State Medical University of the Ministry of Healthcare of Russia; Research Institute of Therapy and Preventive Medicine – a branch of the Federal Research Center “Institute of Cytology and Genetics of the Siberian branch of the Russian Academy of Sciences”
Email: medik11@mail.ru
ORCID iD: 0000-0002-7165-4496
MD, Dr. Sci. (Medicine), professor, professor of the Department of medical genetics and medical biology
Russian Federation, 630005, Novosibirsk, 71 Demyana Bednogo St.; 630089, Novosibirsk, 175/1 B. Bogatkova St.References
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