Possibilities of multi-vector therapy with N-acetylcysteine in the treatment of acute bronchitis

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Abstract

Acute bronchitis (AB) is an acute inflammation of the bronchial tissue, which often occurs in association with upper respiratory tract infections in the absence of chronic bronchopulmonary diseases. Etiologic agent of AB is rarely determined, but in most cases, it is caused by viruses and much less often by bacteria. If the patient has chronic bronchopulmonary pathology (for example, bronchial asthma, chronic bronchitis, chronic obstructive pulmonary disease, bronchiectasis, cystic fibrosis), acute inflammation of the tracheobronchial tree is an exacerbation of the chronic disease, and not AB. It is fundamentally important to distinguish between these clinical situations due to the difference in approaches to their therapy and possible outcomes. In the treatment of OB, symptomatic therapy is used most often. In that case leading role is played by mucoactive drugs, although in some cases it may be necessary to prescribe other groups of medicines – antibiotics, inhaled glucocorticosteroids, antitussives. The aim of the article: to highlight the possibilities of multi-vector therapy of this disease by means of N-acetylcysteine use.

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About the authors

Marina A. Makarova

Pirogov Russian National Research Medical University; Research Institute of Pulmonology; Yudin City Clinical Hospital

Author for correspondence.
Email: mma123@list.ru
ORCID iD: 0000-0003-4913-087X
SPIN-code: 7153-0940

MD, PhD (Medicine), Associate Professor of the Department of Pulmonology of the Institute of Continuous Education and Professional Development; Researcher of the Department of Intensive Care and Respiratory Failure; Pulmonologist of the Department of Respiratory Medicine

Russian Federation, 1/6, Ostrovityanov St., Moscow, 117513; 28/10, Orekhovy Blvd., Moscow, 115682; 4, Kolomensky Dr., Moscow, 115446

Andrey S. Belevsky

Pirogov Russian National Research Medical University

Email: pulmobas@yandex.ru
ORCID iD: 0000-0001-6050-724X
SPIN-code: 7313-8885

MD, Dr. Sci. (Medicine), Professor, President of the Russian Respiratory Society, Chief External Expert Pulmonologist of the Department of Healthcare of the Government of Moscow, Head of the Department of Pulmonology of the Institute of Continuous Education and Professional Development

Russian Federation, 1/6, Ostrovityanov St., Moscow, 117513

Stanislav A. Krasovsky

Research Institute of Pulmonology; Academician Bochkov Medical and Genetic Research Center

Email: sa_krasovsky@mail.ru
ORCID iD: 0000-0001-9642-0947
SPIN-code: 3385-6489

MD, PhD (Medicine), Senior Researcher of the Department of Cystic Fibrosis; Leading Researcher of the Scientific and Clinical Department

Russian Federation, 28/10, Orekhovy Blvd., Moscow, 115682; 1, Moskvorechye St., Moscow, 115478

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