Peculiarities of the course of rheumatoid arthritis in patients with thrombocytosis


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

One of the frequent manifestations of rheumatoid arthritis (RA) is thrombocytosis (platelet count >450x109), but its influence on the course of RA and complications development is not fully solved. Aim: to study features of course of RA on the background of thrombocytosis. Material and methods. The study enrolled 180 patients with RA having average and high degree of activity of the disease, 90 of them had normal level of thrombocytosis and 90 patients with thrombocytosis. Laboratory examination data included assessment of rheumatoid factor (RF), antibodies to cyclic citrullinated peptide (CCP), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), antinuclear factor (ANF), thrombopoietin (TPO), interleukin 6 (IL-6) and soluble p-selectin levels. RA activity was determined by DAS28 (Disease Activity Score). Results. The levels of ESR, CRP, IL-6, TPO, rF and median values of activity of DAS28 by SOE and CRP were significantly higher in subjects with RA and thrombocytosis in comparison with patients with normal level of platelets. In addition, in patients with thrombocytosis, systemic manifestations of RA were significantly more frequently determined. Conclusions. In our study, thrombocytosis was a significant marker of high clinical, laboratory and immunological activity in RA patients. At the same time, platelet counts >450x109 were found to be at high risk for the development of extra-articular manifestations of RA.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Vadim Mazurov

I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia; Clinical Rheumatology Hospital No. 25

Email: maz.nwgmu@yandex.ru
Dr. med. habil., professor, academician of RAS, Honored Worker of Science of the Russian Federation, chief scientific consultant, director of the Research Institute of Rheumatology; head of the Department of therapy, rheumatology, examination of temporary disability and quality of medical care named after E.E. Eichwald; head of the Center for Autoimmune Diseases 191015, Saint Petersburg, 41 Kirochnaya Str

Evgeny Melnikov

I.I. Mechnikov North-Western State Medical University of the Ministry of Healthcare of Russia; Clinical Rheumatology Hospital No. 25

Email: melnikovzhenya@mail.ru
postgraduate student at the Department of therapy, rheumatology, examination of temporary disability and quality of medical care named after E.E. Eichwald; rheumatologist 190068, Saint Petersburg, 30 Bol'shaya Pod'yacheskaya Str

Kira Morozova

Clinical Rheumatology Hospital No. 25

Email: kiramoroba@mail.ru
rheumatologist 190068, Saint Petersburg, 30 Bol'shaya Pod'yacheskaya Str

Victoria Evgrafova

Inlab Genetics LLC

Email: tinakonan@mail.ru
laboratory assistant 192019, Saint Petersburg, 37 Sedova Str

Әдебиет тізімі

  1. Мазуров В.И., Гайдукова И.З., Беляева И.Б. Клиническая ревматология. 3-е издание, переработанное и дополненное. Руководство для врачей. Под ред. В.И. Мазурова. М.: Е-ното. 2021; 696 с. ISBN: 978-5-906023-26-1
  2. Pope J.E., Choy E.H. C-reactive protein and implications in rheumatoid arthritis and associated comorbidities. Semin Arthritis Rheum. 2021; 51(1): 219-29. https://dx.doi.org/10.10167j.semarthrit.2020.11.005.
  3. Yan S., Cui Y., Zhang X. et al. The incidence of extra-articular manifestations in southern Chinese patients with inflammatory joint diseases.Int J Rheum Dis. 2019; 22(9): 1686-94. https://dx.doi.org/10.1111/1756-185X.13657.
  4. Almutairi K., Nossent J., Preen D. et al. 749. The global prevalence of Rheumatoid Arthritis: A meta-analysis.Int J Epidemiol. 2021; 50(1): September dyab168.034. https://dx.doi.org/10.1093/ije/dyab168.034.
  5. Khaled S.A.A., NasrEldin E., Makarem Y.S., Mahmoud H.F.F. Value of platelet distribution width and mean platelet volume in Disease Activity Score of rheumatoid arthritis. J Inflamm Res. 2020; 13: 595-606. https://dx.doi.org/10.2147/JIR.S265811.
  6. Garraud O., Cognasse F. Are platelets cells? And if yes, are they immune cells? Front Immunol. 2015; 6: 70. https://dx.doi.org/10.3389/fimmu.2015.00070.
  7. Amaya-Amaya J., Montoya-Sanchez L., Rojas-Villarraga A. Cardiovascular involvement in autoimmune diseases. Biomed Res Int. 2014; 2014: 367359. https://dx.doi.org/10.1155/2014/367359.
  8. Golebiewska E.M., Poole A.W. Platelet secretion: From haemostasis to wound healing and beyond. Blood Rev. 2015; 29(3): 153-62. https://dx.doi.org/10.1016/j.blre.2014.10.003.
  9. Lukasik Z.M., Makowski M., Makowska J.S. From blood coagulation to innate and adaptive immunity: the role of platelets in the physiology and pathology of autoimmune disorders. Rheumatol Int. 2018; 38(6): 959-74. https://dx.doi.org/10.1007/s00296-018-4001-9.
  10. В.И. Мазуров, Е.С. Мельников, Р.А. Башкинов. Влияние тромбоцитов на течение ревматоидного артрита и сердечно-сосудистый риск. Терапия. 2021; 7(10): 78-88. https://dx.doi.org/10.18565/therapy.2021.10.78-88. EDN IFQACV.
  11. Satacki A.J., Wysokinski A. Reactive thrombocytosis resulting from frequent blood donations as an extremely rare cause of ST segment elevation myocardial infarction in the case of a 19-year-old male. Ann Agric Environ Med. 2018; 25(4): 602-4. https://dx.doi.org/10.26444/aaem/74196.
  12. Al-Ghamdi A., Attar S.M. Extra-articular manifestations of rheumatoid arthritis: A hospital-based study. Ann Saudi Med. 2009; 29(3): 189-93. https://dx.doi.org/10.4103/0256-4947.51774.
  13. Hutchinson R.M., Davis P., Jayson M.I. Thrombocytosis in rheumatoid arthritis. Ann Rheum Dis. 1976; 35(2): 138-42. https://dx.doi.org/10.1136/ard.35.2.138.
  14. Schmitt-Sody M., Metz P., Gottschalk 0. et al. Platelet P-selectin is significantly involved in leukocyte-endothelial cell interaction in murine antigen-induced arthritis. Platelets. 2007; 18(5): 365-72. https://dx.doi.org/10.1080/09537100701191315.
  15. Ertenli I., Kiraz S., Arici M. et al. P-selectin as a circulating molecular marker in rheumatoid arthritis with thrombocytosis. J Rheumatol. 1998; 25(6): 1054-58.
  16. Farr M., Scott D.L., Constable T.J. et al. Thrombocytosis of active rheumatoid disease. Ann Rheum Dis. 1983; 42(5): 545-49. https://dx.doi.org/10.1136/ard.42.5.545.

Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML
Жүктеу

© Bionika Media, 2022

Осы сайт cookie-файлдарды пайдаланады

Біздің сайтты пайдалануды жалғастыра отырып, сіз сайттың дұрыс жұмыс істеуін қамтамасыз ететін cookie файлдарын өңдеуге келісім бересіз.< / br>< / br>cookie файлдары туралы< / a>