Pharmacoeconomic evaluation of genotype-guided dabigatran etexilate dosing in patients with atrial fibrillation and chronic kidney disease
- Авторлар: Mikhaylenko E.V1, Tchubarev V.N1, Abdullaev S.P2, Skripka A.I1, Sychev D.A2
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Мекемелер:
- I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenov University)
- Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian Federation
- Шығарылым: № 4S (2022): Supplement
- Беттер: 79-83
- Бөлім: Articles
- URL: https://journals.eco-vector.com/2412-4036/article/view/277064
- DOI: https://doi.org/10.18565/therapy.2022.4suppl.80-84
- ID: 277064
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Аннотация
Pharmacogenetic testing (PGT) is one of the promising personalized approaches to prescribing drugs in clinical practice. The PGT’s feasibility plays an important role in the oral anticoagulants (DOACs) administration, especially in the event of adverse reactions -hemorrhagic and thrombotic complications. According to the results of our study, personalized pharmacotherapy of dabigatran etexilate 110 and 150 mg reduced the frequency of bleeding (17,79 vs 18,10) and slightly exceeded the cost (cost difference was 216,55 rubles) compared with standard therapy in patients with atrial fibrillation in combination with chronic kidney disease. The PGT application can be used to improve the safety of DOAC pharmacotherapy. In the future, it is possible to decrease the costs of a medical organizations by reducing the cost of genetic tests.
Негізгі сөздер
Толық мәтін
Авторлар туралы
E. Mikhaylenko
I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenov University)
V. Tchubarev
I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenov University)
Sh. Abdullaev
Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian Federation
A. Skripka
I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of the Russian Federation (Sechenov University)
D. Sychev
Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian Federation
Әдебиет тізімі
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- Регистр лекарственных средств России (РЛС). Антикоагулянты/Прадакса® Доступ: https://www.rlsnet.ru/drugs/pradaksa-37149 (дата обращения - 27.05.2022).
- Тарифное соглашение на оплату медицинской помощи, оказываемой по Территориальной программе обязательного медицинского страхования города Москвы на 2022 год. Доступ: https://www.mgfoms.ru/medicinskie-organizacii/tarifi/2022 (дата обращения - 27.05.2022).
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