New data on safety of NSAIDs: concept of the «class-specific» high cardiovascular risk of selective COX-2 inhibitors got out of date
- Авторлар: Karateev A.Y.1, Nasonov Y.L.1, Novikova D.S.1
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Мекемелер:
- V.A. Nasonova Research institute of rheumatology
- Шығарылым: № 2 (2017)
- Беттер: 101-107
- Бөлім: Articles
- URL: https://journals.eco-vector.com/2412-4036/article/view/277675
- ID: 277675
Дәйексөз келтіру
Аннотация
At the end of 2016, the results of the PRECISION study have been published. In this study, 24 081 patients with high cardiovascular risk were receiving celecoxib 200-400 mg/day, naproxen 750-1000 mg/day, or ibuprofen 1800-2400 mg/day for more than 1.5 years (20.3±16.0 months). According to the data received, the frequency of vascular catastrophes (deaths, nonfatal myocardial infarction, and stroke) on the background of use of celecoxib did not exceed the frequency of similar complications when taking control drugs. Furthermore, celecoxib showed a statistically significant benefit in reducing the risk of serious gastrointestinal complications. The new data disproves the concept of «high cardiovascular risk» inherent in all coxibes and confirms the provisions of the national guidelines for the rational use of non-steroidal anti-inflammatory drugs (NSAIDs) published in 2015. This review presents the latest data on the risk of complications with the use of various NSAIDs, including a brief description of the plan and the results of the PRECISION study.
Толық мәтін
Авторлар туралы
Andrey Karateev
V.A. Nasonova Research institute of rheumatologyMD, head of the Laboratory of gastrointestinal problems in rheumatic diseases
Yevgeny Nasonov
V.A. Nasonova Research institute of rheumatologyacademician of RAS, MD, professor, head of the Department of vascular pathology of rheumatic diseases
Diana Novikova
V.A. Nasonova Research institute of rheumatologyPhD, senior researcher of the Laboratory of ultrasound diagnostics
Әдебиет тізімі
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