Сorrection of increased muscular tone using baclofen in diseases and injuries of the nervous system


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Baclofen is a derivative of chlorophenylbutyric acid, and can be considered as a derivative of GABA, which determines the specificity of its pharmacological effects. Therefore, the features of the mechanism of action of the drug can not be considered as definitively clarified [1]. The baclofen-induced miorelaxation is based primarily on the effect at the spinal level and is associated with the suppression of monosynaptic and polysynaptic reflexes, as well as a decrease in the activity of gamma motoneurons. Further evaluation of its mechanisms of action and clinical effectiveness, and the introduction of new dosage forms will help expand the application of this drug in neurological practice.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Andrey Rachîn

Russian Scientific Center of Medical Rehabilitation and Balneology

Email: andrey_ratchin@mail.ru
MD, professor, head of the Department of neurology

Svetlana Vygovskaya

Russian Scientific Center of Medical Rehabilitation and Balneology

PhD, senior researcher, Department of neurology

Margarita Nuvakhova

Russian Scientific Center of Medical Rehabilitation and Balneology

PhD, senior researcher, Department of neurology

Aleksey Voropaev

Russian Scientific Center of Medical Rehabilitation and Balneology

PhD, senior researcher, Department of neurology

Anastasiya Averchenkova

Russian Scientific Center of Medical Rehabilitation and Balneology

PhD, Department of neurology

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