A clinical case of amyloid cardiomyopathy in association of T-cell leukemia

Мұқаба

Дәйексөз келтіру

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Аннотация

The article presents a clinical case of amyloid cardiomyopathy that developed in the presence of T-cell leukemia from large granular lymphocytes. The stages of diagnostic search are described, the causes of late diagnosis of the disease are analyzed. Pathogenetic substantiation of the mechanisms of development of plasma cell monoclonal dyscrasia against the background of T-cell leukemia is given. The presented clinical case shows the complexity and multi-stage character of the diagnosis of amyloid cardiomyopathy, need for rapid diagnosis due to the rapid progression of the disease.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Kristina Klyagina

A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia

Email: mcm3439@yandex.ru
ORCID iD: 0009-0006-7219-6403

clinical resident of the Department of therapy and preventive medicine

Ресей, Moscow

Tatyana Adasheva

A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia

Хат алмасуға жауапты Автор.
Email: adashtv@mail.ru
ORCID iD: 0000-0002-3763-8994

MD, professor, professor of the Department of therapy and preventive medicine

Ресей, Moscow

Elena Mershina

M.V. Lomonosov Moscow State University

Email: elena_mershina@mail.ru

PhD in Medical Sciences, head of the Department of X-ray diagnostics, leading researcher at the Department of radiation diagnostics of the Medical scientific and educational center

Ресей, Moscow

Ekaterina Goruleva

Hospital of the Centrosoyuz of the Russian Federation; Moscow Medical Institute «REAVIZ»

Email: ekaterina.gorulyova@gmail.com
ORCID iD: 0000-0002-7536-7937

PhD in Medical Sciences, associate professor of the Department of internal diseases, head of the therapy Department

Ресей, Moscow; Moscow

Sergey Semochkin

P.A. Herzen Moscow Scientific Research Institute of Oncology – a branch of National Medical Research Center for Radiology of the Ministry of Healthcare of Russia; N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia

Email: semochkin_sv@rsmu.ru
ORCID iD: 0000-0002-8129-8114

MD, head of the group of high-dose chemotherapy and bone marrow transplantation; professor of the Department of oncology, hematology and radiation therapy

Ресей, Moscow; Moscow

Olga Chernysheva

A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia

Email: chernishevaoo@mail.ru
ORCID iD: 0000-0003-4712-1240

6th year student of the Faculty of general medicine

Ресей, Moscow

Natalya Shakhrai

A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia

Email: nholodkova@mail.ru
ORCID iD: 0000-0002-4223-1064

PhD in Medical Sciences, associate professor of the Department of therapy and preventive medicine

Ресей, Moscow

Әдебиет тізімі

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  2. Benson M.D., Buxbaum J.N., Eisenberg D.S. et al. Amyloid nomenclature 2018: Recommendations by the International Society of Amyloidosis (ISA) nomenclature committee. Amyloid. 2018; 25(4): 215–19. https://dx.doi.org/10.1080/13506129.2018.1549825.
  3. Lysenko L.V., Rameev V.V., Moiseev S.V. et al. Clinical guidelines for diagnosis and treatment of systemic amyloidosis. Klinicheskaya farmakologiya i terapiya = Clinical Pharmacology and Therapy. 2020; 29(1): 13–24 (In Russ.). EDN: UCEZAB.
  4. Al-Sergani H., Mourad W., Tabbaa R. Amyloid heart disease. New frontiers and insights in pathophysiology, diagnosis, and management. Tex Heart Inst J. 2005; 32(2): 178–84.
  5. Donnelly J.P., Hanna M. Cardiac amyloidosis: An update on diagnosis and treatment. Cleve Clin J Med. 2017; 84(12 Suppl 3): 12–26. https://dx.doi.org/10.3949/ccjm.84.s3.02.
  6. Siddiqi O.K., Ruberg F.L. Cardiac amyloidosis: An update on pathophysiology, diagnosis, and treatment. Trends Cardiovasc Med. 2018; 28(1): 10–21. https://dx.doi.org/10.1016/j.tcm.2017.07.004.
  7. Garcia-Pavia P., Rapezzi C., Adler Y. et al. Diagnosis and treatment of cardiac amyloidosis: A position statement of the ESC Working Group on Myocardialand Pericardial Diseases. Eur Heart J. 2021: 42(16); 1554–68. https://dx.doi.org/10.1093/eurheartj/ehab072.
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  11. Yaita H., Nakamura S., Kurahara K. et al. Primary small-bowel adult T-cell leukemia/lymphoma with gastric AL amyloidosis. Endoscopy. 2014; 46 Suppl 1 UCTN: E613–14. https://dx.doi.org/10.1055/s-0034-1390757.
  12. Gibson J.F., Kapur L., Sokhn J. et al. A fatal case of primary cutaneous gamma-delta T-cell lymphoma complicated by HLH and cardiac amyloidosis. Clin Case Reports. 2015; 3(1): 34–38. https://dx.doi.org/10.1002/ccr3.142.
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  15. Wennhold K., Thelen M., Lehmann J. et al. Cd86 antigen-presenting b cells are increased in cancer, localize in tertiary lymphoid structures, and induce specific t-cell responses. Cancer Immunol Res. 2021; 9(9): 1098–108. https://dx.doi.org/10.1158/2326-6066.CIR-20-0949.
  16. Calabretto G., Teramo A., Barila G. et al. Neutropenia and large granular lymphocyte leukemia: From pathogenesis to therapeutic options. Cells. 2021; 10(10): 2800. https://dx.doi.org/10.3390/cells10102800.
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1. JATS XML
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2. Fig.1. Diagnosis algorithm for cardiac amyloidosis*

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3. Fig.2. The results of 99mTc-pyrophosphate scintigraphy in patient Z.

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4. Fig.3. Electrocardiogram of patient Z.

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5. Fig.4. The results of echocardiography in patient Z.

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6. Fig.5. Schematic representation of the clinical progression of amyloid cardiomyopathy

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7. Fig.6. Data of magnetic resonance imaging of the heart with intravenous contrast in patient Z.

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8. Fig.7. Mechanism of monoclonal secretion against the background of T-cell leukemia from large granular lymphocytes

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