A clinical case of amyloid cardiomyopathy in association of T-cell leukemia

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Abstract

The article presents a clinical case of amyloid cardiomyopathy that developed in the presence of T-cell leukemia from large granular lymphocytes. The stages of diagnostic search are described, the causes of late diagnosis of the disease are analyzed. Pathogenetic substantiation of the mechanisms of development of plasma cell monoclonal dyscrasia against the background of T-cell leukemia is given. The presented clinical case shows the complexity and multi-stage character of the diagnosis of amyloid cardiomyopathy, need for rapid diagnosis due to the rapid progression of the disease.

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About the authors

Kristina I. Klyagina

A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia

Email: mcm3439@yandex.ru
ORCID iD: 0009-0006-7219-6403

clinical resident of the Department of therapy and preventive medicine

Russian Federation, Moscow

Tatyana V. Adasheva

A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia

Author for correspondence.
Email: adashtv@mail.ru
ORCID iD: 0000-0002-3763-8994

MD, professor, professor of the Department of therapy and preventive medicine

Russian Federation, Moscow

Elena A. Mershina

M.V. Lomonosov Moscow State University

Email: elena_mershina@mail.ru

PhD in Medical Sciences, head of the Department of X-ray diagnostics, leading researcher at the Department of radiation diagnostics of the Medical scientific and educational center

Russian Federation, Moscow

Ekaterina I. Goruleva

Hospital of the Centrosoyuz of the Russian Federation; Moscow Medical Institute «REAVIZ»

Email: ekaterina.gorulyova@gmail.com
ORCID iD: 0000-0002-7536-7937

PhD in Medical Sciences, associate professor of the Department of internal diseases, head of the therapy Department

Russian Federation, Moscow; Moscow

Sergey V. Semochkin

P.A. Herzen Moscow Scientific Research Institute of Oncology – a branch of National Medical Research Center for Radiology of the Ministry of Healthcare of Russia; N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia

Email: semochkin_sv@rsmu.ru
ORCID iD: 0000-0002-8129-8114

MD, head of the group of high-dose chemotherapy and bone marrow transplantation; professor of the Department of oncology, hematology and radiation therapy

Russian Federation, Moscow; Moscow

Olga O. Chernysheva

A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia

Email: chernishevaoo@mail.ru
ORCID iD: 0000-0003-4712-1240

6th year student of the Faculty of general medicine

Russian Federation, Moscow

Natalya B. Shakhrai

A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia

Email: nholodkova@mail.ru
ORCID iD: 0000-0002-4223-1064

PhD in Medical Sciences, associate professor of the Department of therapy and preventive medicine

Russian Federation, Moscow

References

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Supplementary files

Supplementary Files
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1. JATS XML
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2. Fig.1. Diagnosis algorithm for cardiac amyloidosis*

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3. Fig.2. The results of 99mTc-pyrophosphate scintigraphy in patient Z.

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4. Fig.3. Electrocardiogram of patient Z.

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5. Fig.4. The results of echocardiography in patient Z.

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6. Fig.5. Schematic representation of the clinical progression of amyloid cardiomyopathy

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7. Fig.6. Data of magnetic resonance imaging of the heart with intravenous contrast in patient Z.

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8. Fig.7. Mechanism of monoclonal secretion against the background of T-cell leukemia from large granular lymphocytes

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