The use of probiotics containing a combination of Lactobacillus acidophilus LA-5 and Bifidobacterium animalis subsp. lactis BB-12 strains: Meta-analysis of efficacy in the prevention of antibiotic-associated diarrhea and in Helicobacter pylori eradication therapy

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Дәйексөз келтіру

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Аннотация

The efficiency of probiotics in the prevention of antibiotic-associated diarrhea (AAD) and H. pylori eradication therapy remains the subject of debate.

The primary objectives of this systematic review and meta-analysis were to access the effectiveness of the use of combination of Lactobacillus acidophilus LA-5 and Bifidobacterium animalis subsp. lactis BB-12, including as a part of other probiotics in the prevention of AAD and as well as in H. pylori eradication therapy.

Material and methods. We searched in PubMed database from January 1, 2000 to December 31, 2022. Additionally, we performed an extensive search in the literature references on the relevant topic. Screening of studies, selection, evaluation of the quality and suitability of studies for inclusion in a systematic review were performed by two independent experts. Data analysis and extraction were carried out using the PRISMA flowchart. The RevMan 5.4.1 program was used for the meta-analysis. The included publications were full-text articles with detailed information about clinical studies using a combination of LA-5 and BB-12, including as part of other probiotics.

Results. A total of 278 studies met the inclusion criteria were identified. 7 studies (n=1052) were included in the meta-analysis of AAD risk. Use of LA-5 and BB-12 combination decreased AAD risk by 46% (RR 0,54; 95% CI: 0,33–0,91; 5 studies, n=742). Three studies (n=339) were included in the meta-analysis of H. pylori eradication outcomes. The use of combination of LA-5 and BB-12 led to a statistically significant increase in the chances of successful eradication of H. pylori (OR 2,42; 95% CI: 1,34–4,34), risk of adverse events was decreased by 70% (RR 0,30; 95% CI: 0,20–0,46; 2 studies, n=201), and diarrhea risk was lowered by 65% (RR 0,35; 95% CI: 0,19–0,65; 3 studies, n=339).

Conclusion. The results of the meta-analysis showed that the use of probiotics in the form of combination of LA-5 and BB-12 strains is associated with a reduced risk of AAD, including patients undergoing H. pylori eradication infection, as well as with a lower frequency of adverse events during eradication therapy.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Alexander Gorelov

Central Research Institute of Epidemiology of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Email: zdn@pcr.ru
ORCID iD: 0000-0001-9257-0171

MD, professor, academician of RAS, deputy director for scientific work of Central Research Institute of Epidemiology of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing

Ресей, Moscow

Irina Andreeva

Institute of Antimicrobial Chemotherapy of Smolensk State Medical University

Email: Irina.Andreeva@antibiotic.ru
ORCID iD: 0000-0001-7916-1488

PhD in Medical Sciences, associate professor, head of the Department for development of clinical guidelines of Institute of Antimicrobial Chemotherapy, Smolensk State Medical University

Ресей, Smolensk

Sergey Zakharenko

Children’s Scientific and Clinical Center for Infectious Diseases of Federal Medical and Biological Agency

Email: zsm1@mail.ru
ORCID iD: 0000-0001-8666-6118

PhD in Medical Sciences, associate professor, deputy director of Children’s Scientific and Clinical Center for Infectious Diseases of Federal Medical and Biological Agency

Ресей, Saint Petersburg

Alexander Sinopalnikov

Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of Russia

Хат алмасуға жауапты Автор.
Email: aisyn@list.ru
ORCID iD: 0000-0002-1990-2042

MD, professor, Honored Doctor of the Russian Federation, head of the Department of pulmonology, Russian Medical Academy of Continuing Professional Education of the Ministry of Healthcare of Russia

Ресей, Moscow

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1. JATS XML
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2. Fig. 1. Search strategy for publications for meta-analysis

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3. Fig. 2. Summary meta-analysis of the effectiveness of probiotics on the risk of antibiotic-associated diarrhea

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4. Fig. 3. Effect of the combination of LA-5 and BB-12 on the frequency of eradication of Helicobacter pylori infection

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5. Fig. 4. The effect of the combination of LA-5 and BB-12 on the risk of adverse events during eradication therapy

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6. Fig. 5. The effect of the combination of LA-5 and BB-12 on the risk of developing diarrhea during eradication therapy

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