Tongue and fingers gangrene - a rare manifestation of systemic ANCA-associated vasculitis

A. V Skvortsov; Скворцов А. В; N. M Bulanov; Буланов Н. М; Yu. D Sorokin; Сорокин Ю. Д; B. B Saltykov; Салтыков Б. Б; P. I Novikov; Новиков П. И; S. V Moiseev; Моисеев С. В

doi:10.18565/therapy.2021.6.98-103

Tongue and fingers gangrene - a rare manifestation of systemic ANCA-associated vasculitis

Autores: Skvortsov A.V¹, Bulanov N.M¹, Sorokin Y.D¹, Saltykov B.B¹, Novikov P.I¹, Moiseev S.V¹
Afiliações:
1. I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)
Edição: Volume 7, Nº 6 (2021)
Páginas: 98-103
Seção: Articles
URL: https://journals.eco-vector.com/2412-4036/article/view/288421
DOI: https://doi.org/10.18565/therapy.2021.6.98-103
ID: 288421

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Systemic vasculitis associated with antibodies to the cytoplasm of neutrophils (ANCA) is a group of autoimmune diseases characterized by inflammatory damage of small vessels of various organs. Despite frequent damage of skin and mucous membranes, the development of soft tissue gangrene for ANCA-associated vasculitis is not common. The article presents a clinical observation of female patient, whose clinical course of the generalized form of ANCA-associated vasculitis was complicated by tongue and fingers' necrotic changes formation. Despite the intravital diagnosis and timely initiation of immunosuppressive therapy, the severe course of the disease led to the development of multiple organ failure and death. Diagnosis was confirmed by autopsy, during which tongue arterioles vasculitis signs were revealed, which made it possible to fix the genesis of necrotic changes and their direct connection with main disease.

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antibodies to the cytoplasm of neutrophils, immunosuppressive therapy, gangrene, glomerulonephritis

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Bibliografia

Jennette J.C., Falk R.J., Bacon P.A. et al. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum. 2013; 65(1): 1-11. doi: 10.1002/art.37715.
Kumarasinghe A.P., Hepburn A., Reuther W.J., Pratt C. Temporal arteritis presenting with tongue necrosis. BMJ Case Rep. 2012; 2012: bcr2012007241. doi: 10.1136/bcr-2012-007241.
Schurr C., Berthele A., Burghartz M., Kiefer J. Spontaneous bilateral necrosis of the tongue: a manifestation of giant cell arteritis? Eur Arch Otorhinolaryngol. 2008; 265(8): 993-98. doi: 10.1177/1179547619857690.
DeBord L.C., Chiu I., Liou N.E. Delayed diagnosis of giant cell arteritis in the setting of isolated lingual necrosis. Clin Med Insights Case Rep. 2019; 12: 1179547619857690. doi: 10.1177/1179547619857690.
Rodgers H., Quirke P., Lipkin G.W., Brownjohn A.M. Infarction of the tongue in Wegener's granulomatosis. Br J Clin Pract. 1992; 46(4): 268-69.
Bachmeyer B., Petitjean B., Testart F. et al. Lingual necrosis as the presenting sign of Wegener's granulomatosis. Clin Exp Dermatol. 2006; 31(2): 321-22. doi: 10.1111/j.1365-2230.2005.02053.x.
Carter L.M., Brizman E. Lingual infarction in Wegener's granulomatosis: A case report and review of the literature. Head Face Med. 2008; 4: 19. doi: 10.1186/1746-160X-4-19.
O'Neill J., Shaw-Dunn J., Robertson S., Rea P. Arterial anastomosis in the tongue. J Oral Maxillofac Surg. 2016; 74(5): 1084-90. doi: 10.1016/j.joms.2015.12.011.

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Tongue and fingers gangrene - a rare manifestation of systemic ANCA-associated vasculitis

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Resumo

Palavras-chave

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Sobre autores

A. Skvortsov

N. Bulanov

Yu. Sorokin

B. Saltykov

P. Novikov

S. Moiseev

Bibliografia

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