Clinical-functional and molecular-genetic peculiarities of patients with chronic heart failure
- Autores: Zimina Y.D.1, Gerasimenko O.N.1, Voronina E.N.2, Tolmacheva A.A.1
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Afiliações:
- Novosibirsk State Medical University of the Ministry of Healthcare of Russia
- Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences
- Edição: Volume 10, Nº 4 (2024)
- Páginas: 41-49
- Seção: ORIGINAL STUDIES
- URL: https://journals.eco-vector.com/2412-4036/article/view/634442
- DOI: https://doi.org/10.18565/therapy.2024.4.41-49
- ID: 634442
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Resumo
Patients with chronic heart failure (CHF) have a large number of comorbid conditions that can aggravate the course of the disease. Gender peculiarities also play an important role, but the mechanisms of CHF development in male and female individualв in comparison have not been fully studied. Molecular genetic research is a modern direction in studying the risk of CHF development and progression, but a literature review shows their ambiguous results, which indicates the importance of further research in this area.
The aim: to evaluate clinical, functional and molecular genetic characteristics of patients with CHF.
Material and methods. The study included 157 patients (average age 68.9 ± 9.5 years) with diagnosed CHF, who underwent laboratory, instrumental and molecular genetic studies (polymorphisms rs632793 of NPPB gene and rs5065 of NPPA gene). The participants were divided into two groups: the 1st group included male pesons (n = 79), the 2nd group included female persons (n = 78). Next, among the study persons (n = 157), a subgroup of patients with the results of molecular genetic study was identified in the quantity of 68 persons (36 males and 32 females).
Results and conclusion. Among all studied patients (n = 157), stage IIa CHF (52.3%, n = 82), III functional class of the disease (63%, n = 99), CHF with preserved ejection fraction (52.8%, n = 83) were most common. When assessing comorbid pathologies, the leading position was occupied by hypertension (96.8%, n = 152). In the group of male patients, persons of working age were more common (p < 0.001). When analyzing comorbid conditions, a significantly higher frequency of permanent atrial fibrillation (AF) was revealed in the group of men (p = 0.04). According to the results of laboratory and instrumental examination methods, no significant differences were identified. A correlation was found between the rs632793 polymorphism of NPPB gene and AF in CHF in female patients (odds ratio 6.600; 95% confidence interval: 1.229–35.439; p = 0.02). Obtained data could be used for personalized assessment of the risk of AF developing in case of CHF.
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Sobre autores
Yulia Zimina
Novosibirsk State Medical University of the Ministry of Healthcare of Russia
Autor responsável pela correspondência
Email: yulya_tx@mail.ru
ORCID ID: 0000-0001-9027-6884
MD, postgraduate student of the Department of Faculty Therapy named after Professor G.D. Zalessky of the Faculty of General Medicine
Rússia, NovosibirskOksana Gerasimenko
Novosibirsk State Medical University of the Ministry of Healthcare of Russia
Email: profgerasimenko@inbox.ru
ORCID ID: 0000-0002-9742-0479
MD, Dr. Sci. (Medicine), professor, head of the Department of Faculty Therapy named after Professor G.D. Zalessky of the Faculty of General Medicine
Rússia, NovosibirskElena Voronina
Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences
Email: voronina_l@mail.ru
MD, PhD (Biology), head of the group, senior researcher at the Molecular Genetics Group
Rússia, NovosibirskAnastasia Tolmacheva
Novosibirsk State Medical University of the Ministry of Healthcare of Russia
Email: tolmacheva_nastena@mail.ru
ORCID ID: 0000-0003-1687-4100
MD, PhD (Medicine), assistant at the Department of Faculty Therapy named after Professor G.D. Zalessky of the Faculty of General Medicine
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