Role of computed tomographic dynamic myocardial perfusion in the diagnosis of functional significance of coronary artery stenosis
- 作者: Dmitrieva D.S.1, Filatova D.A.1, Pavlikova E.P.1, Krasnova T.N.1, Mershina E.A.1, Lisitskaya M.V.1, Trukhanova M.A.1, Seredenina E.M.1, Vaypan D.V.1, Polyakov R.S.1, Vartanyan E.L.1, Sinitsyn V.E.1
-
隶属关系:
- M.V. Lomonosov Moscow State University
- 期: 卷 10, 编号 6 (2024)
- 页面: 112-121
- 栏目: CLINICAL CASES
- URL: https://journals.eco-vector.com/2412-4036/article/view/636378
- DOI: https://doi.org/10.18565/therapy.2024.6.112-121
- ID: 636378
如何引用文章
详细
The presented clinical case demonstrates the use of computed tomographic (CT) angiography for assessment of myocardial perfusion in a comorbid patient with coronary heart disease. According to non-invasive tests data, the patient had borderline stenosis (70%) in the right coronary artery. Estimation the functional significance of stenosis in this case was complicated, because due to comorbidity, in particular the presence of chronic obstructive pulmonary disease (COPD), patient experienced difficulties in performing standard stress tests; in addition, their results were not informative, since shortness of breath could be not only the equivalent of ischemia, but also a manifestation of COPD. Methodic of cardiac CT with pharmacological stress myocardial perfusion assessment made it possible to verify myocardial ischemia, and its results were comparable to the data of invasive coronary angiography. Article discusses the prospects for using CT coronary angiography with myocardial perfusion assessment in clinical practice.
全文:

作者简介
Daria Dmitrieva
M.V. Lomonosov Moscow State University
编辑信件的主要联系方式.
Email: Sergeevna_D9@mail.ru
ORCID iD: 0009-0002-0748-0273
MD, 2nd year resident doctor of the Department of internal medicine of Medical Research and Educational Center
俄罗斯联邦, MoscowDaria Filatova
M.V. Lomonosov Moscow State University
Email: dariafilatova.msu@mail.ru
ORCID iD: 0000-0002-0894-1994
MD, postgraduate student of the Department of radiation diagnostics and therapy, radiologist at the Department of X-ray diagnostics with MRI and CT rooms of Research and Educational Center
俄罗斯联邦, MoscowElena Pavlikova
M.V. Lomonosov Moscow State University
Email: elena.pavlikova@inbox.ru
ORCID iD: 0000-0001-7693-5281
MD, Dr. Sci (Medicine), professor of the Department of internal medicine of the Faculty of fundamental medicine, deputy director for clinical work, chief physician of the Medical Research and Educational Center
俄罗斯联邦, MoscowTatyana Krasnova
M.V. Lomonosov Moscow State University
Email: krasnovamgu@yandex.ru
ORCID iD: 0000-0001-6175-1076
MD, PhD (Medicine), head of the Department of internal diseases of the Faculty of fundamental medicine, leading researcher at the Department of internal diseases of the Medical Research and Educational Center
俄罗斯联邦, MoscowElena Mershina
M.V. Lomonosov Moscow State University
Email: elena_mershina@mail.ru
ORCID iD: 0000-0002-1266-4926
MD, PhD (Medicine), associate professor of the Department of radiation diagnostics and therapy, head of the Department of X-ray diagnostics with MRI and CT rooms at the Medical Research and Educational Center
俄罗斯联邦, MoscowMaria Lisitskaya
M.V. Lomonosov Moscow State University
Email: Sergeevna_D9@mail.ru
ORCID iD: 0000-0002-8402-7643
MD, PhD (Medicine), radiologist at the Department of X-ray diagnostics with MRI and CT rooms at the Medical Research and Educational Center
俄罗斯联邦, MoscowMaria Trukhanova
M.V. Lomonosov Moscow State University
Email: tryxanova@yandex.ru
ORCID iD: 0000-0002-9957-4906
MD, PhD (Medicine), anesthesiologist-resuscitator, researcher at the Department of internal medicine of the Medical Research and Educational Center
俄罗斯联邦, MoscowElena Seredenina
M.V. Lomonosov Moscow State University
Email: e.m.seredenina@gmail.com
ORCID iD: 0000-0002-1490-2078
MD, PhD (Medicine), head of the Department of therapy, senior researcher at the Department of age-associated diseases of the Medical Research and Educational Center
俄罗斯联邦, MoscowDaniil Vaypan
M.V. Lomonosov Moscow State University
Email: vdv_zao@mail.ru
MD, general practitioner, researcher at the Department of internal diseases of the Medical Research and Educational Center, assistant at the Department of internal medicine of the Faculty of fundamental medicine
俄罗斯联邦, MoscowRoman Polyakov
M.V. Lomonosov Moscow State University
Email: Roman.polyakov@gmail.com
ORCID iD: 0000-0002-9323-4003
MD, Dr. Sci. (Medicine), head of the Department of X-ray surgical methods of diagnostics and treatment of the Medical Research and Educational Center
俄罗斯联邦, MoscowErik Vartanyan
M.V. Lomonosov Moscow State University
Email: Sergeevna_D9@mail.ru
ORCID iD: 0000-0001-6757-7101
MD, PhD (Medicine), doctor for X-ray endovascular diagnostics and treatment of the Medical Research and Educational Center
俄罗斯联邦, MoscowValentin Sinitsyn
M.V. Lomonosov Moscow State University
Email: vsini@mail.ru
ORCID iD: 0000-0002-5649-2193
MD, Dr. Sci. (Medicine), professor, head of the Department of radiation diagnostics of the Medical Research and Educational Center, head of the Department of radiation diagnostics and therapy of the Faculty of fundamental medicine
俄罗斯联邦, Moscow参考
- Барбараш О.Л., Карпов Ю.А., Кашталап В.В. с соавт. Стабильная ишемическая болезнь сердца. Клинические рекомендации 2020. Российский кардиологический журнал. 2020; 25(11): 201–250. [Barbarash O.L., Karpov Yu.A., Kashtalap V.V. et al. 2020 Clinical practice guidelines for Stable coronary artery disease. Rossijskiy kardiologicheskij zhurnal = Russian Journal of Cardiology. 2020; 25(11): 201–250 (In Russ.)]. https://doi.org/10.15829/1560-4071-2020-4076. EDN: THCMQS.
- Карпов Ю.А., Кухарчук В.В., Лякишев А.А. с соавт. Диагностика и лечение хронической ишемической болезни сердца. Кардиологический вестник. 2015; 10(3): 3–33. [Karpov Yu.A., Kukharchuk V.V., Lyakishev A.A. et al. Diagnosis and treatment of chronic ischemic heart disease. Kardiologicheskiy vestnik = Cardiology Bulletin. 2015; 10(3): 3–33 (In Russ.)]. EDN: UKKHIJ.
- Knuuti J., Ballo H., Juarez-Orozco L.E. et al. The performance of non-invasive tests to rule-in and rule-out significant coronary artery stenosis in patients with stable angina: A meta-analysis focused on post-test disease probability. Eur Heart J. 2018; 39(35): 3322–30. https://doi.org/10.1093/eurheartj/ehy267. PMID: 29850808.
- Hoffmann U., Ferencik M., Udelson J.E. et al. Prognostic value of noninvasive cardiovascular testing in patients with stable chest pain: Insights from the PROMISE trial (Prospective Multicenter Imaging Study for Evaluation of Chest Pain). Circulation. 2017; 135(24): 2320–32. https://doi.org/10.1161/circulationaha.116.024360. PMID: 28389572. PMCID: PMC5946057.
- Knuuti J., Wijns W., Saraste A. et al. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. Eur Heart J. 2020; 41(3): 407–77. https://doi.org/10.1093/eurheartj/ehz425. PMID: 31504439.
- García-Baizan A., Millor M., Bartolome P. et al. Adenosine triphosphate (ATP) and adenosine cause similar vasodilator effect in patients undergoing stress perfusion cardiac magnetic resonance imaging. Int J Cardiovasc Imaging. 2019; 35(4): 675–82. https://doi.org/10.1007/s10554-018-1494-y. PMID: 30426300.
- Чучалин А.Г., Авдеев С.Н., Айсанов З.Р. с соавт. Хроническая обструктивная болезнь легких: федеральные клинические рекомендации по диагностике и лечению. Пульмонология. 2022; 32(3): 356–392. [Chuchalin A.G., Avdeev S.N., Aisanov Z.R. et al. Federal guidelines on diagnosis and treatment of chronic obstructive pulmonary disease. Pulmonologiya = Pulmonology. 2022; 32(3): 356–392 (In Russ.)]. https://doi.org/10.18093/0869-0189-2022-32-3-356-392. EDN: ANYVUN.
- Верткин А.Л., Скотников А.С., Тихоновская Е.Ю. с соавт. Коморбидность при ХОБЛ: роль хронического системного воспаления. РМЖ. 2014; 22(11): 811–816. [Vertkin A.L., Skotnikov A.S., Tikhonovskaya E.Yu. et al. Comorbidity in patients with chronic obstructive lung disease: the role of chronic systemic inflammation. Russkiy meditsinskiy zhurnal = Russian Medical Journal. 2014; 22(11): 811–816 (In Russ.)]. EDN: SKBNMF.
- Greenwood J.P., Ripley D.P., Berry C. et al. Effect of care guided by cardiovascular magnetic resonance, myocardial perfusion scintigraphy, or NICE guidelines on subsequent unnecessary angiography rates: The CE-MARC 2 randomized clinical trial. JAMA. 2016; 316(10): 1051–60. https://doi.org/10.1001/jama.2016.12680. PMID: 27570866.
- Siontis G.C., Mavridis D., Greenwood J.P. et al. Outcomes of non-invasive diagnostic modalities for the detection of coronary artery disease: Network meta-analysis of diagnostic randomised controlled trials. BMJ. 2018; 360: k504. https://doi.org/10.1136/bmj.k504. PMID: 29467161. PMCID: PMC5820645.
- Wang Y., Qin L., Shi X. et al. Adenosine-stress dynamic myocardial perfusion imaging with second-generation dual-source CT: Comparison with conventional catheter coronary angiography and SPECT nuclear myocardial perfusion imaging. AJR Am J Roentgenol. 2012; 198(3): 521–29. https://doi.org/10.2214/AJR.11.7830. PMID: 22357991.
- Tomizawa N., Chou S., Fujino Y. et al. Feasibility of dynamic myocardial CT perfusion using single-source 64-row CT. J Cardiovasc Comput Tomogr. 2019; 13(1): 55–61. https://doi.org/10.1016/j.jcct.2018.10.003. PMID: 30309765.
- Seitun S., Castiglione Morelli M., Budaj I. et al. Stress computed tomography myocardial perfusion imaging: A new topic in cardiology. Rev Esp Cardiol. 2016; 69(2): 188–200. https://doi.org/10.1016/j.rec.2015.10.018. PMID: 26774540.
- Danad I., Szymonifka J., Schulman-Marcus J. et al. Static and dynamic assessment of myocardial perfusion by computed tomography. Eur Heart J Cardiovasc Imaging. 2016; 17(8): 836–44. https://doi.org/10.1093/ehjci/jew044. PMID: 27013250. PMCID: PMC4955293.
- Meinel F.G., Ebersberger U., Schoepf U.J. et al. Global quantification of left ventricular myocardial perfusion at dynamic CT: Feasibility in a multicenter patient population. AJR Am J Roentgenol. 2014; 203(2): W174–80. https://doi.org/10.2214/ajr.13.12328. PMID: 24848691.
- Huber A.M., Leber V., Gramer B.M. et al. Myocardium: Dynamic versus single-shot CT perfusion imaging. Radiology. 2013;269(2): 378–86. https://doi.org/10.1148/radiology.13121441. PMID: 23788717.
补充文件
