Влияние тромбоцитов на течение ревматоидного артрита и сердечно-сосудистый риск


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Аннотация

Распространенность ревматоидного артрита (РА) в мире оценивается в 0,46%. Среди внесуставных проявлений этого заболевания особенно выделяется патология органов сердечнососудистой системы, которая, по данным литературы, является основной причиной смертности среди пациентов с РА, достигая 39,6%. Кроме традиционных кардиоваскулярных факторов риска, независимым предиктором сердечно-сосудистых заболеваний (ССЗ) служит хроническое системное воспаление, характерное для РА. Этот факт нашел отражение в современных шкалах расчета риска сердечно-сосудистых осложнений (ССО), включающих наличие системного воспаления (в том числе при РА). Распространенность повышения уровня тромбоцитов в крови у пациентов с РА неизвестна. Остается не до конца изученной роль тромбоцитоза в течении РА и его вклад в формирование ССЗ и увеличение риска ССО. Цель настоящего обзора - представить данные международной литературы, в которых изучалась связь тромбоцитов и повышения их уровня при РА с течением воспалительного процесса и их влияние на органы сердечно-сосудистой системы.

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Вадим Иванович Мазуров

ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России; СПб ГБУЗ «Клиническая ревматологическая больница № 25»

Email: maz.nwgmu@yandex.ru
д.м.н., профессор, академик РАН, заслуженный деятель науки РФ, главный научный консультант, директор НИИ ревматологии; зав. кафедрой терапии, ревматологии, экспертизы временной нетрудоспособности и качества медицинской помощи им. Э.Э. Эйхвальда

Евгений Сергеевич Мельников

ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России; СПб ГБУЗ «Клиническая ревматологическая больница № 25»

Email: melnikovzhenya@mail.ru
аспирант кафедры терапии, ревматологии, экспертизы временной нетрудоспособности и качества медицинской помощи им. Э.Э. Эйхвальда; врач-ревматолог

Роман Андреевич Башкинов

ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России; СПб ГБУЗ «Клиническая ревматологическая больница № 25»

Email: evgeniy.trofimov@szgmu.ru
аспирант кафедры терапии, ревматологии, экспертизы временной нетрудоспособности и качества медицинской помощи им. Э.Э. Эйхвальда; врач-ревматолог

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