Effect of platelets on the course of rheumatoid arthritis and cardiovascular risk


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Abstract

The prevalence of rheumatoid arthritis (RA) is estimated at 0,46% of the world population. In addition to the musculoskeletal system, the disease may have various extra-articular manifestations, including cardiovascular pathology. According to the literature, cardiovascular pathology is the main cause of death among patients with RA, reaching 39,6%. Apart from traditional risk factors of cardiovascular diseases (CVD), chronic systemic inflammation, characteristic for RA, is an independent predictor of cardiovascular pathology. This fact is reflected in modern scales of cardiovascular risk (CVR) calculation, which include the presence of systemic inflammation (including in RA) to avoid underestimating their impact on cardiovascular risks. The prevalence of elevated blood platelet levels in patients with RA is unknown. The role of thrombocytosis in the course of RA and its contribution to the formation of CVD and increased risk of CVR remains incompletely understood. This review presents data from the international literature, which studied the impact of platelets and platelet elevation in patients with RA on the course of the inflammatory process and the impact on cardiovascular organs.

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About the authors

Vadim I. Mazurov

I.I. Mechnikov North-West State Medical University of the Ministry of Healthcare of Russia; Clinical Rheumatology Hospital No. 25, Saint Petersburg

Email: maz.nwgmu@yandex.ru
MD, professor, academician of RAS, Honored worker of science of Russian Federation, Director of the Research Institute of Rheumatology; head of the Department of therapy, rheumatology, examination of temporary disability and quality of medical care named after E.E. Eichwald

Evgeny S. Melnikov

I.I. Mechnikov North-West State Medical University of the Ministry of Healthcare of Russia; Clinical Rheumatology Hospital No. 25, Saint Petersburg

Email: melnikovzhenya@mail.ru
postgraduate student at the Department of therapy, rheumatology, examination of temporary disability and quality of medical care named after E.E. Eichwald; rheumatologist

Roman Andreevich Bashkinov

I.I. Mechnikov North-West State Medical University of the Ministry of Healthcare of Russia; Clinical Rheumatology Hospital No. 25, Saint Petersburg

Email: evgeniy.trofimov@szgmu.ru
postgraduate student at the Department of therapy, rheumatology, examination of temporary disability and quality of medical care named after E.E. Eichwald; rheumatologist

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