Active tuberculosis process in female patient with asymptomatic clinical course of malignant neoplasm in the pulmonary tissue

封面

如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅或者付费存取

详细

In modern phthisiology, the problem of combination of pulmonary tuberculosis and malignant neoplasms (MN) is actual. According to research data, in case of MN, the risk of tuberculosis arising in patients increases by 6 times. At the same time, the presence of an active tuberculosis process (ATP) in lung tissue increases the probability of lung cancer by 3 times or more. In addition, the interaction of these two diseases can reduce the anti-tumor effect of immune system. This situation can lead to a long-term asymptomatic clinical course of oncological process coming secondary to active pulmonary tuberculosis. The aim of the article is to demonstrate the combination of ATP and asymptomatic clinical course of malignant neoplasms. The presented clinical example demonstrates the difficulties of diagnosis and choice of treatment tactics in such category of patients. Actual direction in modern phthisiology is high oncological alertness to comorbid patients with pulmonary tuberculosis.

全文:

受限制的访问

作者简介

Nikita Chumovatov

Central Research Institute of Tuberculosis

编辑信件的主要联系方式.
Email: Necro5412@mail.ru
ORCID iD: 0000-0001-8745-7940

MD, PhD (Medicine), researcher at the Department of phthisiology

俄罗斯联邦, 107564, Moscow, 2 Yauzskaya Alley

Asel Ainsanova

Central Research Institute of Tuberculosis

Email: asel.ainsanova@gmail.com
ORCID iD: 0009-0001-5593-6872

MD, laboratory assistant-researcher at the Department of phthisiology

俄罗斯联邦, 107564, Moscow, 2 Yauzskaya Alley

Natalya Chernykh

Central Research Institute of Tuberculosis

Email: natadok@inbox.ru
ORCID iD: 0000-0001-6787-2362

MD, PhD (Medicine), senior researcher at the Department of phthisiology

俄罗斯联邦, 107564, Moscow, 2 Yauzskaya Alley

Andrey Khozikov

Central Research Institute of Tuberculosis

Email: hozikov96@mail.ru
ORCID iD: 0000-0003-0308-9592

MD, pathologist

俄罗斯联邦, 107564, Moscow, 2 Yauzskaya Alley

Oksana Komissarova

Central Research Institute of Tuberculosis; N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia

Email: oksana.komissarova.72@mail.ru
ORCID iD: 0000-0003-4427-3804

MD, Dr. Sci. (Medicine), associate professor, deputy director for scientific and medical work of the Department of phthisiology

俄罗斯联邦, 107564, Moscow, 2 Yauzskaya Alley; 1 bldg. 6 Ostrovityanova ulitsa, Moscow 117513

参考

  1. Васильева И.А., Тестов В.В., Стерликов С.А. Эпидемическая ситуация по туберкулезу в годы пандемии COVID-19 – 2020–2021 гг. Туберкулез и болезни легких. 2022; 100(3): 6–12. [Vasilyeva I.A., Testov V.V., Sterlikov S.A. Tuberculosis situation in the years of the COVID-19 pandemic – 2020–2021. Tuberkulez i bolezni legkikh = Tuberculosis and Lung Diseases. 2022; 100(3): 6–12 (In Russ.)]. https://doi.org/10.21292/2075-1230-2022-100-3-6-12. EDN: DPMDCF.
  2. Cheng M.P., Chakra C.N.A., Yansouni C.P. et al. Risk of active tuberculosis in patients with cancer: A systematic review and meta-analysis. Clin Infect Dis. 2017; 64(5): 635–44. https://doi.org/10.1093/cid/ciw838. PMID: 27986665.
  3. Engels E.A., Shen M., Chapman R.S. et al. Tuberculosis and subsequent risk of lung cancer in Xuanwei, China. Int J Cancer. 2009; 124(5): 1183–87. https://doi.org/10.1002/ijc.24042. PMID: 19058197. PMCID: PMC2610239.
  4. An S.J., Kim Y.-J., Han S.-S., Heo J. Effects of age on the association between pulmonary tuberculosis and lung cancer in a South Korean cohort. J Thorac Dis. 2020; 12(3): 375–82. https://doi.org/10.21037/jtd.2020.01.38. PMID: 32274103. PMCID: PMC7139000.
  5. Gong W., Liang Y., Wu X. Animal models of tuberculosis vaccine research: An important component in the fight against tuberculosis. Biomed Res Int. 2020; 2020: 4263079. https://doi.org/10.1155/2020/4263079. PMID: 32025519. PMCID: PMC6984742.
  6. Mi J., Liang Y., Liang J. et al. The research progress in immunotherapy of tuberculosis. Front Cell Infect Microbiol. 2021; 11: 763591. https://doi.org/10.3389/fcimb.2021.763591. PMID: 34869066. PMCID: PMC8634162.

补充文件

附件文件
动作
1. JATS XML
2. Fig. 1. Axial sections of computed tomography of the chest organs of the patient observed on 07/05/2024, pulmonary window: A - focal infiltrative changes in the upper lobe of the right lung, B - rounded formation in the lower lobe of the left lung

下载 (1MB)
3. Fig. 2. Axial sections of computed tomography of the chest organs of the patient observed on 09/06/2024, pulmonary window: A - partial resorption of focal infiltrative changes, B - rounded formation in the lower lobe of the left lung

下载 (983KB)
4. Fig. 3. Macroscopic specimen of the lung of the observed patient: a nodular formation of a whitish-gray color with a weakly fibrous structure was detected in the lung tissue

下载 (1MB)
5. Fig. 4. Pathohistological picture of the surgical material of the observed patient

下载 (2MB)

版权所有 © Bionika Media, 2025