Favorable course of pregnancy in a patient with rituximab-induced remission of granulomatosis with polyangiitis

Granulomatosis with polyangiitis (GPA) is a rare autoimmune disease affecting small and medium-caliber arteries and mainly affecting the ENT organs, lungs and kidneys. Pregnancy in GPA patients is rare due to the development of the disease in most females over the age of 40–50 years. At the same time, when these conditions are combined, there is a high risk of exacerbation of GPA, which is life-threatening for the mother and requires the use of aggressive immunosuppression with potentially teratogenic drugs, which further increases the risk of complications for the fetus. Management of such a pregnancy requires careful monitoring and an interdisciplinary approach. Article contains a clinical observation of a young patient with severe lung damage associated with GPA, including the stages of diagnosis, selection of therapy, pregnancy and postpartum period. The aim of describing the presented clinical case is to illustrate the possibilities of a favorable pregnancy outcome for the mother and child when planning it during the period of GPA remission.