Favorable course of pregnancy in a patient with rituximab-induced remission of granulomatosis with polyangiitis
- Authors: Yupatova M.I.1, Nikitina N.M.1, Rebrov A.P.1
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Affiliations:
- V.I. Razumovsky Saratov State Medical University of the Ministry of Healthcare of Russia
- Issue: Vol 11, No 2 (2025)
- Pages: 114-118
- Section: CLINICAL CASES
- URL: https://journals.eco-vector.com/2412-4036/article/view/683408
- DOI: https://doi.org/10.18565/therapy.2025.2.114-118
- ID: 683408
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Abstract
Granulomatosis with polyangiitis (GPA) is a rare autoimmune disease affecting small and medium-caliber arteries and mainly affecting the ENT organs, lungs and kidneys. Pregnancy in GPA patients is rare due to the development of the disease in most females over the age of 40–50 years. At the same time, when these conditions are combined, there is a high risk of exacerbation of GPA, which is life-threatening for the mother and requires the use of aggressive immunosuppression with potentially teratogenic drugs, which further increases the risk of complications for the fetus. Management of such a pregnancy requires careful monitoring and an interdisciplinary approach. Article contains a clinical observation of a young patient with severe lung damage associated with GPA, including the stages of diagnosis, selection of therapy, pregnancy and postpartum period. The aim of describing the presented clinical case is to illustrate the possibilities of a favorable pregnancy outcome for the mother and child when planning it during the period of GPA remission.
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About the authors
Maria I. Yupatova
V.I. Razumovsky Saratov State Medical University of the Ministry of Healthcare of Russia
Author for correspondence.
Email: agent.smi@mail.ru
ORCID iD: 0000-0001-8120-4424
SPIN-code: 4436-4561
Scopus Author ID: 59315471700
MD, assistant at the Department of hospital therapy of the Institute of clinical medicine
Russian Federation, SaratovNatalya M. Nikitina
V.I. Razumovsky Saratov State Medical University of the Ministry of Healthcare of Russia
Email: nikina02@yandex.ru
ORCID iD: 0000-0002-0313-1191
SPIN-code: 6661-1830
Scopus Author ID: 24338688700
MD, Dr. Sci. (Medicine), head of the Department of hospital therapy of the Institute of clinical medicine
Russian Federation, SaratovAndrey P. Rebrov
V.I. Razumovsky Saratov State Medical University of the Ministry of Healthcare of Russia
Email: aprebrov@yandex.ru
ORCID iD: 0000-0002-3463-7734
SPIN-code: 9574-2067
Scopus Author ID: 7005047527
MD, Dr. Sci. (Medicine), professor of the Department of hospital therapy of the Institute of clinical medicine, plenipotentiary representative of RSMSIM in the Volga Federal District
Russian Federation, SaratovReferences
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