Prognostic value of placental growth factor (PlGF) in “white-coat hypertension” in pregnant individuals
- Autores: Nikolenko E.S.1, Chulkov V.S.2, Syundyukova E.G.1, Sumerkina V.A.1, Pykhova L.R.1, Chulkov V.S.1
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Afiliações:
- South Ural State Medical University of the Ministry of Healthcare of Russia
- Yaroslav-the-Wise Novgorod State University
- Edição: Volume 11, Nº 5 (2025)
- Páginas: 57-64
- Seção: ORIGINAL STUDIES
- URL: https://journals.eco-vector.com/2412-4036/article/view/688977
- DOI: https://doi.org/10.18565/therapy.2025.5.57-64
- ID: 688977
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Resumo
“White-coat hypertension” (WCH) in pregnant individuals is associated with an increased risk of adverse pregnancy outcomes.
The aim: to establish a correlation between the levels of placental growth factor (PlGF) in the second trimester of pregnancy and preeclampsia in females with WCH.
Material and methods. Observational prospective study included 88 pregnant individuals, divided into 2 groups: 1st – 44 females with WCH, 2nd – 44 women with normal blood pressure (BP). Estimation of clinical factors, 24-hour blood pressure monitoring, laboratory and instrumental studies, assessment of serum PlGF, analysis of the course and outcomes of pregnancy was performed.
Results. The most common cardiometabolic risk factors in pregnant individuals with WCH were abdominal obesity and anamnestic data on previous preeclampsia. According to 24-hour BP monitoring data, pregnant women with WCH had higher systolic and diastolic BP during the day and at night, as well as average daytime heart rate, comparatively to pregnant individuals with normal BP. In the presence of WCH, the course of pregnancy was more often complicated by gestational diabetes mellitus, preeclampsia, premature birth, placental abruption, low birth weight babies, and antenatal fetal death. The threshold value of PlGF ≤ 179.74 pg/ml, measured at 14–20 weeks of pregnancy, showed sufficient prognostic value for late preeclampsia (area under the ROC curve is 0.815, sensitivity 80.0%, specificity 77.78%).
Conclusion. PlGF can be used as a predictor of preeclampsia development in pregnant individuals with WCH.
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Sobre autores
Ekaterina Nikolenko
South Ural State Medical University of the Ministry of Healthcare of Russia
Email: nikolenkokate@yandex.ru
ORCID ID: 0000-0003-4958-4695
Código SPIN: 2336-1822
MD, assistant at the Department of faculty therapy
Rússia, ChelyabinskVasily Chulkov
Yaroslav-the-Wise Novgorod State University
Email: vschulkov@rambler.ru
ORCID ID: 0000-0002-0952-6856
Código SPIN: 8001-0051
MD, Dr. Sci. (Medicine), professor of the Department of internal medicine
Rússia, Veliky NovgorodElena Syundyukova
South Ural State Medical University of the Ministry of Healthcare of Russia
Email: seg269@mail.ru
ORCID ID: 0000-0001-9535-1871
MD, Dr. Sci. (Medicine), associate professor, professor of the Department of obstetrics and gynaecology
Rússia, ChelyabinskVeronika Sumerkina
South Ural State Medical University of the Ministry of Healthcare of Russia
Email: veronika.sumerkina@mail.ru
ORCID ID: 0000-0003-4842-0875
Código SPIN: 5831-4416
MD, PhD (Medicine), head of the Central Research Department
Rússia, ChelyabinskLyubov Pykhova
South Ural State Medical University of the Ministry of Healthcare of Russia
Email: Lyubov_pykhova@mail.ru
ORCID ID: 0000-0003-0658-7626
Código SPIN: 3226-6247
MD, PhD (Biology), biologist at the Research Institute of Immunology
Rússia, ChelyabinskVladislav Chulkov
South Ural State Medical University of the Ministry of Healthcare of Russia
Autor responsável pela correspondência
Email: vlad.chulkov.1989@mail.ru
ORCID ID: 0000-0002-1948-8523
Código SPIN: 4425-4640
MD, PhD (Medicine), associate professor of the Department of faculty therapy
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