Доказательная база антикоагулянтной терапии при сочетании фибрилляции предсердий и сахарного диабета

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Аннотация

Пероральная антикоагулянтная терапия – убедительно доказанный способ снижения смертности пациентов с фибрилляцией предсердий (ФП). Однако до сих пор не проводилось специальных рандомизированных клинических исследований пероральных антикоагулянтов у больных с сочетанием ФП и сахарного диабета (СД) с оценкой клинических исходов.

Цель обзора – проанализировать современные литературные данные об эффективности и безопасности пероральных антикоагулянтов с фокусом на ривароксабан для обоснованного выбора тактики их применения у больных с сочетанием ФП и СД. Поиск литературных источников проводился в электронных базах eLibrary.ru и PubMed для выявления статей, опубликованных с 2015 по 2025 г. В обзоре представлены патофизиологическая связь ФП и СД, варианты антикоагулянтной терапии у пациентов с сочетанием этих заболеваний, результаты важнейших сравнительных исследований пероральных антикоагулянтов при лечении таких пациентов. Также сопоставлено влияние отдельных вариантов антикоагулянтной терапии на функцию почек, обсужден ряд преимуществ прямых пероральных антикоагулянтов в сравнении с варфарином.

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Сергей Григорьевич Канорский

ФГБОУ ВО «Кубанский государственный медицинский университет» Минздрава России

Автор, ответственный за переписку.
Email: kanorskysg@mail.ru
ORCID iD: 0000-0003-1510-9204
SPIN-код: 7635-5330

д. м. н., профессор, заведующий кафедрой терапии № 2

Россия, г. Краснодар

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