Evidentiary basis of anticoagulant therapy in case of atrial fibrillation and diabetes mellitus combination

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Oral anticoagulant therapy is a convincingly proven method for reducing mortality in patients with atrial fibrillation (AF). However, until the present, no special randomized clinical trials of oral anticoagulants in patients with combination of AF and diabetes mellitus (DM) with an assessment of clinical outcomes have been performed.

The aim of the review is to analyze current literature data on the efficacy and safety of oral anticoagulants with a focus on rivaroxaban for a substantiated choice of tactics for their use in patients with AF and DM combination. Literature search was performed in electronic databases eLibrary.ru and PubMed to identify articles published from 2015 to 2025. The review presents pathophysiological correlation between AF and diabetes mellitus, options for anticoagulant therapy in patients with a combination of these diseases, and the results of the most important comparative studies of oral anticoagulants in the treatment of such kind of patients. Influence of individual options of anticoagulant therapy at renal function is also compared, and a number of advantages of direct oral anticoagulants comparatively to warfarin are discussed.

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Sergey Kanorsky

Kuban State Medical University of the Ministry of Healthcare of Russia

编辑信件的主要联系方式.
Email: kanorskysg@mail.ru
ORCID iD: 0000-0003-1510-9204
SPIN 代码: 7635-5330

MD, Dr. Sci. (Medicine), professor, head of the Department of therapy No. 2

俄罗斯联邦, Krasnodar

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