Sharpe’s syndrome. Difficulties in diagnosis


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详细

A modern doctor faces a huge number of similar or overlapping sympthoms and syndromes that comprise a disease pattern and need a thorough differential-diagnostic approach while diagnosis verification. In this connection a mixed connective tissue disease (MCTD) takes pride of place. Sharp's syndrome is an autoimmune mixed connective tissue disease which is characterized by the presence of separate symptoms of systemic lupus erythematosus (SLE), systemic sclerosis (SSc), polymyositis (PM) and rheumatoid arthritis (RA), in combination with a high titer of anti-U 1 ribonucleoprotein (RNP) antibodies. As a rule the prognosis of Sharp's syndrome is favourable and a clinical remission is possible. However the presence of pulmonary hypertension, renal damage and severe Raynaud's syndrome causes worse prognosis, which is described in the below mentioned clinical event.

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作者简介

Argishti Vardanyan

Pirogov Russian National Research Medical University of the Ministry of Health care of Russia

Email: argisht@mail.ru
assistant of the Department of Hospital Therapy No. 1

Ivan Gordeev

Pirogov Russian National Research Medical University of the Ministry of Health care of Russia

Email: vnsoboleva@yandex.ru
MD, Professor, Head of the Department of Hospital Therapy No. 1

Valentina Soboleva

Pirogov Russian National Research Medical University of the Ministry of Health care of Russia

Email: drvolov@yandex.ru
MD PhD, Associate Professor of the Department of Hospital Therapy No. 1

Nikolai Volov

Pirogov Russian National Research Medical University of the Ministry of Health care of Russia

Email: alfilenko@rambler.ru
MD PhD, Associate Professor of the Department of Hospital Therapy No. 1

Yulia Mashukova

Pirogov Russian National Research Medical University of the Ministry of Health care of Russia

Email: bezdolnova@yandex.ru
MD PhD, Associate Professor of the Department of Hospital Therapy No. 1

Elena Bezdolnova

Pirogov Russian National Research Medical University of the Ministry of Health care of Russia

a student of the Department of Hospital Therapy No. 1

Varvara Rymberg

Pirogov Russian National Research Medical University of the Ministry of Health care of Russia

a student of the Department of Hospital Therapy No. 1

Ella Ramazanova

Pirogov Russian National Research Medical University of the Ministry of Health care of Russia

a student of the Department of Hospital Therapy No. 1

Ararat Nazaryan

Pirogov Russian National Research Medical University of the Ministry of Health care of Russia

Email: cardio-15@0yandex.ru
a student of the Department of Hospital Therapy No. 1

参考

  1. Ревматология: национальное руководство / под ред. Е.Л. Насонова, В.А. Насоновой. М.: ГЭОТАР-Медиа, 2010. 720 с.
  2. Eric L. Greidinger. Mixed Connective-Tissue Disease, 2017.
  3. Ian R. Mackay, Noel R. Rose. The Autoimmune Diseases II, 1991. 464 p.
  4. Клиническая ревматология (руководство для врачей) / под ред. чл.-корр. РАМН проф. В.И. Мазурова. 2-е изд., пере-раб. и доп. - СПб: ООО «Издательство ФОЛИАНТ», 2005. 520 с.
  5. Amigues J.M., Cantagrel A., Abbai M., Mazieres B. Comparative study of 4 diagnosis criteria sets for mixed connective tissue diseases in patients with anti-RNP antibodies. J. Rheumatol., 1996.

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