Sharpe’s syndrome. Difficulties in diagnosis


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Abstract

A modern doctor faces a huge number of similar or overlapping sympthoms and syndromes that comprise a disease pattern and need a thorough differential-diagnostic approach while diagnosis verification. In this connection a mixed connective tissue disease (MCTD) takes pride of place. Sharp's syndrome is an autoimmune mixed connective tissue disease which is characterized by the presence of separate symptoms of systemic lupus erythematosus (SLE), systemic sclerosis (SSc), polymyositis (PM) and rheumatoid arthritis (RA), in combination with a high titer of anti-U 1 ribonucleoprotein (RNP) antibodies. As a rule the prognosis of Sharp's syndrome is favourable and a clinical remission is possible. However the presence of pulmonary hypertension, renal damage and severe Raynaud's syndrome causes worse prognosis, which is described in the below mentioned clinical event.

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About the authors

Argishti Gagikovich Vardanyan

Pirogov Russian National Research Medical University of the Ministry of Health care of Russia

Email: argisht@mail.ru
assistant of the Department of Hospital Therapy No. 1

Ivan Gennadevich Gordeev

Pirogov Russian National Research Medical University of the Ministry of Health care of Russia

Email: vnsoboleva@yandex.ru
MD, Professor, Head of the Department of Hospital Therapy No. 1

Valentina Nikolaevna Soboleva

Pirogov Russian National Research Medical University of the Ministry of Health care of Russia

Email: drvolov@yandex.ru
MD PhD, Associate Professor of the Department of Hospital Therapy No. 1

Nikolai Alexandrovich Volov

Pirogov Russian National Research Medical University of the Ministry of Health care of Russia

Email: alfilenko@rambler.ru
MD PhD, Associate Professor of the Department of Hospital Therapy No. 1

Yulia Mikhailovna Mashukova

Pirogov Russian National Research Medical University of the Ministry of Health care of Russia

Email: bezdolnova@yandex.ru
MD PhD, Associate Professor of the Department of Hospital Therapy No. 1

Elena Olegovna Bezdolnova

Pirogov Russian National Research Medical University of the Ministry of Health care of Russia

a student of the Department of Hospital Therapy No. 1

Varvara Pavlovna Rymberg

Pirogov Russian National Research Medical University of the Ministry of Health care of Russia

a student of the Department of Hospital Therapy No. 1

Ella Sergeevna Ramazanova

Pirogov Russian National Research Medical University of the Ministry of Health care of Russia

a student of the Department of Hospital Therapy No. 1

Ararat Khachikovich Nazaryan

Pirogov Russian National Research Medical University of the Ministry of Health care of Russia

Email: cardio-15@0yandex.ru
a student of the Department of Hospital Therapy No. 1

References

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  2. Eric L. Greidinger. Mixed Connective-Tissue Disease, 2017.
  3. Ian R. Mackay, Noel R. Rose. The Autoimmune Diseases II, 1991. 464 p.
  4. Клиническая ревматология (руководство для врачей) / под ред. чл.-корр. РАМН проф. В.И. Мазурова. 2-е изд., пере-раб. и доп. - СПб: ООО «Издательство ФОЛИАНТ», 2005. 520 с.
  5. Amigues J.M., Cantagrel A., Abbai M., Mazieres B. Comparative study of 4 diagnosis criteria sets for mixed connective tissue diseases in patients with anti-RNP antibodies. J. Rheumatol., 1996.

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