Combined drug therapy of post-traumatic osteoarthritis: data from a three-year prospective study
- 作者: Trofimov E.A.1, Mazurov V.I.1
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隶属关系:
- North-Western State Medical University named after I.I. Mechnikov of the Ministry of Healthcare of Russia
- 期: 卷 7, 编号 4 (2021)
- 页面: 155-161
- 栏目: Articles
- URL: https://journals.eco-vector.com/2412-4036/article/view/288239
- DOI: https://doi.org/10.18565/therapy.2021.4.155-161
- ID: 288239
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详细
As a part of the original research we performed MRI T2-mapping for the structural changes tracking on the early stages of post-traumatic knee osteoarthritis. It was found that at this stage of the disease a significant importance is not only the formation of osteophytes but also a decrease in the bonds number between the collagen-proteoglycan complex and water molecules, reflected by such an important parameter as a change in the relaxation time of the T2-signal, which is detected using the T2-mapping technique. During the 36-month study, we evaluated the influence of combined schemes of osteoarthritis therapy with the disease-modifying drugs on the clinical manifestations, as well as on the X-ray parameters of the early stages of the disease. Combined therapy with the usage of SYSADOA leads to a significant clinical improvement in accordance with the questionnaires data and slows the chrondrodegeneration progression in regard to the MRI data with the usage of color T2-mapping of cartilage.
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作者简介
Evgeniy Trofimov
North-Western State Medical University named after I.I. Mechnikov of the Ministry of Healthcare of Russia
Email: kafterrevm@szgmu.ru
PhD, associate professor of the Department of therapy, rheumatology, examination of temporary disability and medical care quality named after E.E. Eichwald 191015, Saint Petersburg, 41 Kirochnaya Str
Vadim Mazurov
North-Western State Medical University named after I.I. Mechnikov of the Ministry of Healthcare of Russia
Email: kafterrevm@szgmu.ru
MD, professor, academician of RAS, head of the Department of therapy, rheumatology, examination of temporary disability and medical care quality named after E.E. Eichwald 191015, Saint Petersburg, 41 Kirochnaya Str
参考
- Мазуров В.И., Трофимова А.С., Трофимов Е.А. Факторы риска и некоторые аспекты патогенеза остеоартрита. Вестник Северо-Западного государственного медицинского университета им. И.И. Мечникова. 2016; 2: 116-24.
- Мазуров В.И., Лесняк О.М. Ревматология. Фармакотерапия без ошибок. М.: Е-ното. 2017; 528 с. ISBN: 978-5-90602317-9.
- Трофимова А.С., Кахели М.А., Трофимов Е.А. Лучевая диагностика остеоартроза. Лучевая диагностика и терапия. 2016; 3: 25-32.
- Лила А.М., Трофимова А.С., Трофимов Е.А. Остеоартрит. СПб.: Издательство СЗГМУ. 2017; 48 с.
- Bruyere O., Cooper C., Pelletier J.P. et al. An algorithm recommendation for the management of knee osteoarthritis in Europe and internationally: A report from a task force of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Semin Arthritis Rheum. 2014; 44(3): 253-63. doi: 10.1016/j.semarthrit.2014.05.014.
- Денисов Л.Н., Цветкова Е.С., Голубев Г.Ш. с соавт. Алгоритм лечения остеоартрита коленного сустава Европейского общества по клиническим и экономическим аспектам остеопороза и остеоартрита (ESCEO) применим в Российской клинической практике: совместное заключение ведущих российских специалистов и экспертов ESCEO по остеоартриту. Научно-практическая ревматология. 2016; 6: 641-653. doi: https://doi.org/10.14412/1995-4484-2016-641-653.
- Мазуров В.И., Трофимова А.С. Применение методики цветового картирования хрящевой ткани для оценки эффективности терапии остеоартрита. Вестник Новгородского государственного университета. 2016; 6: 44-48.
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