Frequency of detecting markers of hepatitis C among the conditionally healthy population of Tatarstan Republic


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Population studies are important for understanding the full epidemiological situation in certain regions of Russia, and obtained data should be taken into account when creating regional screening programs for hepatitis C virus (HCV) detection. The aim of the study is to determine the true prevalence of HCV markers among the apparently healthy population of Tatarstan Republic (RT). Material and methods. 913 samples of blood sera from a conditionally healthy population of Tatarstan Republic were studied. The sample included persons of 9 age groups: under one year old, 1-9 years old, 10-14 years old, 15-19 years old, 20-29 years old, 30-39 years old, 40-49 years old, 50-59 years old and over 60 years old. The presence of antibodies to the virus in the samples was checked by EIA methodic in screening and confirmatory test. All anti-HCV positive participants were screened for the presence of an ongoing infectious process by detecting HCV RNA by means of RT-PCR methodic. In samples positive for HCV RNA, the genotype of the virus was also fixed. Results. Anti-HCV detection rates in average consisted of 2.1% (19/913; 95% CI: 1,3-3,2%), and the prevalence of current infection confirmed by HCV RNA detection was 0,9% (8/913; 95 % CI: 0,4-1,7%). In age cohorts over 60 and 30-39 years old, there were significant differences in the incidence of HCV RNA comparatively with other study groups, the analyzed index was 3,4% (4/119; 95% CI: 1,0-8,6%) and 2,7% (3/112; 95% CI: 0,5-7,9%), respectively. Phylogenetic analysis showed the division of the studied HCV isolates into subtypes 1a (n=1), 1b (n=2), 2a (n=2) and 3a (n=3). Conclusion. In general, among the conditionally healthy population of Tatarstan Republic, an average level of prevalence of HCV infection was revealed. Individuals aged 30-39 years and older than 60 years are the cohorts in which more careful monitoring of the spread of HCV is needed, while the presence of risk factors for infection is an index of less diagnostical importance.

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作者简介

Vera Kichatova

I.I. Mechnikov Scientific Research Institute of Vaccines and Serums; Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia

Email: vera_kichatova@mail.ru
PhD in Medicine, researcher at the Laboratory of viral hepatitis

Karen Kyuregyan

I.I. Mechnikov Scientific Research Institute of Vaccines and Serums; Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia; Peoples' Friendship University of Russia

Email: karen-kyuregyan@yandex.ru
Dr. habil. biol., professor of RAS, chief researcher at Research Institute of Molecular and Personalized Medicine

Anastasia Carlsen

I.I. Mechnikov Scientific Research Institute of Vaccines and Serums; Peoples' Friendship University of Russia

Email: karlsen12@gmail.com
researcher at Research and Educational Resource Center «High-Performance Methods of Genomic Analysis»

Ilya Potemkin

I.I. Mechnikov Scientific Research Institute of Vaccines and Serums; Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia

Email: axi0ma@mail.ru
PhD in Medicine, researcher at the Department of viral hepatitis studies, Research Institute of Molecular and Personalized Medicine

Fedor Asadi Mobarkhan

I.I. Mechnikov Scientific Research Institute of Vaccines and Serums; Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia

Email: 1amfa@bk.ru
researcher at the Department of viral hepatitis studies, Research Institute of Molecular and Personalized Medicine; researcher at the Laboratory of viral hepatitis

Olga Isaeva

I.I. Mechnikov Scientific Research Institute of Vaccines and Serums; Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia

Email: isaeva.06@mail.ru
PhD in Biology, leading researcher at the Department of viral hepatitis studies; leading researcher at the Laboratory of viral hepatitis

Maria Lopatukhina

I.I. Mechnikov Scientific Research Institute of Vaccines and Serums

Email: m.lopatukhina@gmail.com
researcher at the Laboratory of viral hepatitis

Elena Malinnikova

I.I. Mechnikov Scientific Research Institute of Vaccines and Serums; Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia

Email: malinacgb@mail.ru
Dr. med. habil., professor, head of the Department of virology; leading researcher at the Laboratory of viral hepatitis

Irina Kravchenko

Kazan State Medical University of the Ministry of Healthcare of Russia

Email: kravchencoie@mail.ru
Dr. med. habil., professor of the Department of infectious diseases

Olga Znoyko

A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia

Email: olgaznoyko@yandex.ru
Dr. med. habil., professor of the Department of infectious diseases and epidemiology

Nikolai Yuschuk

A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of Russia

Dr. med. habil., professor, academician of RAS, president

Mikhail Mikhailov

I.I. Mechnikov Scientific Research Institute of Vaccines and Serums; Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russia

Email: michmich2@yandex.ru
Dr. med. habil., professor, corresponding member of RAS, scientific director of Research Institute of Molecular and Personalized Medicine; head of the Laboratory of viral hepatitis

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