Ulceronecrotic ANCA-associated vasculitis with a rare BPI-antibody type


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详细

Article presents a clinical case of cutaneous vasculitis with systemic manifestations in an elderly female patient. The difficulty of making diagnosis was due to the atypical character of antibodies and combination of the pathology with bacterial infection on type 2 diabetes mellitus background. Immunohistochemical examination of biopsy specimens from the affected skin areas was the key diagnostic method, which allowed to make correct diagnosis and prescribe successful treatment.

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作者简介

Luiza Lukmanova

Bashkir State Medical University of the Ministry of Healthcare of Russia

rheumatologist

Yan Bayazitov

City Clinical Hospital No. 13 of the Republic of Bashkortostan

pathologist, head of the centralized pathoanatomical Department

Anton Tyurin

Bashkir State Medical University of the Ministry of Healthcare of Russia

PhD in Medicine, associate professor, head of the Department of internal medicine

参考

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  2. Csernok E. The diagnostic and clinical utility of autoantibodies in systemic vasculitis. Antibodies (Basel). 2019; 8(2): 31. https://dx.doi.org/10.3390/antib8020031.
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  5. Fukuhara A., Tanino Y., Sato S. et al. Systemic vasculitis associated with anti-neutrophil cytoplasmic antibodies against bactericidal/permeability increasing protein. Intern Med. 2013; 52(10): 1095-99. https://dx.doi.org/10.2169/internalmedicine.52.9477.
  6. Schultz H., Schinke S., Weiss J. et al. BPI-ANCA in transporter associated with antigen presentation (TAP) deficiency: Possible role in susceptibility to Gram-negative bacterial infections. Clin Exp Immunol. 2003; 133(2): 252-59. https://dx.doi.org/10z1046/j.1365-2249.2003.02197.x.

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