Ulceronecrotic ANCA-associated vasculitis with a rare BPI-antibody type
- Autores: Lukmanova L.Z.1, Bayazitov Y.I.2, Tyurin A.V.1
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Afiliações:
- Bashkir State Medical University of the Ministry of Healthcare of Russia
- City Clinical Hospital No. 13 of the Republic of Bashkortostan
- Edição: Volume 8, Nº 6 (2022)
- Páginas: 92-96
- Seção: Articles
- URL: https://journals.eco-vector.com/2412-4036/article/view/289151
- DOI: https://doi.org/10.18565/therapy.2022.6.92-96
- ID: 289151
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Resumo
Article presents a clinical case of cutaneous vasculitis with systemic manifestations in an elderly female patient. The difficulty of making diagnosis was due to the atypical character of antibodies and combination of the pathology with bacterial infection on type 2 diabetes mellitus background. Immunohistochemical examination of biopsy specimens from the affected skin areas was the key diagnostic method, which allowed to make correct diagnosis and prescribe successful treatment.
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Sobre autores
Luiza Lukmanova
Bashkir State Medical University of the Ministry of Healthcare of Russiarheumatologist
Yan Bayazitov
City Clinical Hospital No. 13 of the Republic of Bashkortostanpathologist, head of the centralized pathoanatomical Department
Anton Tyurin
Bashkir State Medical University of the Ministry of Healthcare of RussiaPhD in Medicine, associate professor, head of the Department of internal medicine
Bibliografia
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- Zhao M., Jones S., Lockwood C. Bactericidal/permeability-increasing protein (BPI) is an important antigen for anti-neutrophil cytoplasmic autoantibodies (ANCA) in vasculitis. Clin Exp Immunol. 1995; 99(1): 49-56. https ://dx.doi.org/10.1111/j.1365-2249.1995.tb03471.x.
- Takeda S., Watanabe-Kusunoki K., Nakazawa D. et al. The pathogenicity of BPI-ANCA in a patient with systemic vasculitis. Front Immunol. 2019; 10: 1334. https://dx.doi.org/10.3389/fimmu.2019.01334.
- Fukuhara A., Tanino Y., Sato S. et al. Systemic vasculitis associated with anti-neutrophil cytoplasmic antibodies against bactericidal/permeability increasing protein. Intern Med. 2013; 52(10): 1095-99. https://dx.doi.org/10.2169/internalmedicine.52.9477.
- Schultz H., Schinke S., Weiss J. et al. BPI-ANCA in transporter associated with antigen presentation (TAP) deficiency: Possible role in susceptibility to Gram-negative bacterial infections. Clin Exp Immunol. 2003; 133(2): 252-59. https://dx.doi.org/10z1046/j.1365-2249.2003.02197.x.
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