Clinical observation of a patient with primary hypoparathyroidism, uncontrolled hypocalcemia and heart failure

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Hypocalcemia and associated symptoms are common manifestations of postoperative hypoparathyroidism clinical picture. Meanwhile, there are not so many patients with hypocalcemia occurring due to primary hypoparathyroidism, manifested by heart failure (HF). Current article describes a clinical case of a 45-year-old female patient with primary hypoparathyroidism and uncontrolled hypocalcemia, in whom acute HF was developed, and was accompanied by a significant decrease in the left ventricular ejection fraction and heart cavities dilatation. After normalization of the calcium level in the blood serum, the clinical symptoms of HF regressed, cardiac function normalized. That rare case has shown the key role of calcium in maintaining cardiac function in such kind of patients, as well as the critical importance of abolition the reversible causes of HF.

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作者简介

Yulia Katushkina

Scientific Research Institute – Regional Clinical Hospital No. 1 named after professor S.V. Ochapovsky; Kuban State Medical University of the Ministry of Healthcare of Russia

编辑信件的主要联系方式.
Email: ukadoc@gmail.com
ORCID iD: 0009-0009-7334-9928

endocrinologist at the department of endocrinology, assistant at the department of therapy no. 1 of the faculty of advanced training and professional retraining of specialists

俄罗斯联邦, 350901, Krasnodar, 140 Rossiyskaya Str.; Krasnodar

Zoya Tatarintseva

Scientific Research Institute – Regional Clinical Hospital No. 1 named after professor S.V. Ochapovsky

Email: z.tatarintseva@list.ru
ORCID iD: 0000-0002-3868-8061

head of the department of cardiology

俄罗斯联邦, 350901, Krasnodar, 140 Rossiyskaya Str.

Elena Kosmacheva

Scientific Research Institute – Regional Clinical Hospital No. 1 named after professor S.V. Ochapovsky; Kuban State Medical University of the Ministry of Healthcare of Russia

Email: kosmachova_h@mail.ru
ORCID iD: 0000-0001-5690-2482

md, professor, head of the department of therapy no. 1 of the faculty of advanced training and professional retraining of specialists, deputy chief physician for the medical part 

俄罗斯联邦, 350901, Krasnodar, 140 Rossiyskaya Str.; Krasnodar

Galina Petrik

Scientific Research Institute – Regional Clinical Hospital No. 1 named after professor S.V. Ochapovsky; Kuban State Medical University of the Ministry of Healthcare of Russia

Email: pgg@mail.ru
ORCID iD: 0000-0003-4145-5602

md, professor of the department of therapy no. 1 of the faculty of advanced training and professional retraining of specialists, endocrinologist 

俄罗斯联邦, 350901, Krasnodar, 140 Rossiyskaya Str.; Krasnodar

参考

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  2. de Oliveira Martins Duarte J., Pestana Pereira P.M.L., Sobral A.S.G. et al A rare and reversible case of heart failure: Hypocalcemia due to hypoparathyroidism. Clin Case Rep. 2019; 7(10): 1932–34. https://dx.doi.org/10.1002/ccr3.2397.
  3. Parepa I., Mazilu L., Suceveanu A. et al. Hypocalcemic cardiomyopathy: A rare heart failure etiology in adult. Acta Endocrinol (Buchar). 2019; 5(1): 107–12. https://dx.doi.org/10.4183/aeb.2019.107.
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  5. Bansal B., Bansal M., Bajpai P. et al. Hypocalcemic cardiomyopathy: Different mechanisms in adult and pediatric cases. J Clin Endocrinol Metab. 2014; 99(8): 2627–32. https://dx.doi.org/10.1210/jc.2013-3352.
  6. Shoback D.M., Bilezikian J.P., Costa A.G. et al. Presentation of hypoparathyroidism: Etiologies and clinical features. J Clin Endocrinol Metab. 2016; 101(6): 2300–12. https://dx.doi.org/10.1210/jc.2015-3909.
  7. Kim S.H., Rhee Y., Kim Y.M. et al Prevalence and complications of nonsurgical hypoparathyroidism in Korea: A nationwide cohort study. PLoS One. 2020; 15(5): e0232842. https://dx.doi.org/10.1371/journal.pone.0232842.
  8. Gosmanova E.O., Chen K., Ketteler M. et al. Risk of cardiovascular conditions in patients with chronic hypoparathyroidism: A retrospective cohort study. Adv Ther. 2021; 38(8): 4246–57. https://dx.doi.org/10.1007/s12325-021-01787-7.
  9. Solzbach U., Kitterer H.R., Haas H. Reversible congestive heart failure in severe hypocalcemia. Herz. 2010; 35(7): 507–10.
  10. https://dx.doi.org/10.1007/s00059-010-3374-7.

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