Clinical observation of a patient with primary hypoparathyroidism, uncontrolled hypocalcemia and heart failure
- Autores: Katushkina Y.A.1,2, Tatarintseva Z.G.1, Kosmacheva E.D.1,2, Petrik G.G.1,2
-
Afiliações:
- Scientific Research Institute – Regional Clinical Hospital No. 1 named after professor S.V. Ochapovsky
- Kuban State Medical University of the Ministry of Healthcare of Russia
- Edição: Volume 9, Nº 6 (2023)
- Páginas: 90-97
- Seção: CL INICAL CASE
- URL: https://journals.eco-vector.com/2412-4036/article/view/624548
- DOI: https://doi.org/10.18565/therapy.2023.6.90–97
- ID: 624548
Citar
Texto integral
Acesso aberto
Acesso está concedido
Acesso é pago ou somente para assinantes
Resumo
Hypocalcemia and associated symptoms are common manifestations of postoperative hypoparathyroidism clinical picture. Meanwhile, there are not so many patients with hypocalcemia occurring due to primary hypoparathyroidism, manifested by heart failure (HF). Current article describes a clinical case of a 45-year-old female patient with primary hypoparathyroidism and uncontrolled hypocalcemia, in whom acute HF was developed, and was accompanied by a significant decrease in the left ventricular ejection fraction and heart cavities dilatation. After normalization of the calcium level in the blood serum, the clinical symptoms of HF regressed, cardiac function normalized. That rare case has shown the key role of calcium in maintaining cardiac function in such kind of patients, as well as the critical importance of abolition the reversible causes of HF.
Palavras-chave
Texto integral
Sobre autores
Yulia Katushkina
Scientific Research Institute – Regional Clinical Hospital No. 1 named after professor S.V. Ochapovsky; Kuban State Medical University of the Ministry of Healthcare of Russia
Autor responsável pela correspondência
Email: ukadoc@gmail.com
ORCID ID: 0009-0009-7334-9928
endocrinologist at the department of endocrinology, assistant at the department of therapy no. 1 of the faculty of advanced training and professional retraining of specialists
Rússia, 350901, Krasnodar, 140 Rossiyskaya Str.; KrasnodarZoya Tatarintseva
Scientific Research Institute – Regional Clinical Hospital No. 1 named after professor S.V. Ochapovsky
Email: z.tatarintseva@list.ru
ORCID ID: 0000-0002-3868-8061
head of the department of cardiology
Rússia, 350901, Krasnodar, 140 Rossiyskaya Str.Elena Kosmacheva
Scientific Research Institute – Regional Clinical Hospital No. 1 named after professor S.V. Ochapovsky; Kuban State Medical University of the Ministry of Healthcare of Russia
Email: kosmachova_h@mail.ru
ORCID ID: 0000-0001-5690-2482
md, professor, head of the department of therapy no. 1 of the faculty of advanced training and professional retraining of specialists, deputy chief physician for the medical part
Rússia, 350901, Krasnodar, 140 Rossiyskaya Str.; KrasnodarGalina Petrik
Scientific Research Institute – Regional Clinical Hospital No. 1 named after professor S.V. Ochapovsky; Kuban State Medical University of the Ministry of Healthcare of Russia
Email: pgg@mail.ru
ORCID ID: 0000-0003-4145-5602
md, professor of the department of therapy no. 1 of the faculty of advanced training and professional retraining of specialists, endocrinologist
Rússia, 350901, Krasnodar, 140 Rossiyskaya Str.; KrasnodarBibliografia
- Chou C.T., Siegel B., Mehta D. Stridor and apnea as the initial presentation of primary hypoparathyroidism. Int J Pediatr Otorhinolaryngol. 2016; 80: 30–32. https://dx.doi.org/10.1016/j.ijporl.2015.11.023.
- de Oliveira Martins Duarte J., Pestana Pereira P.M.L., Sobral A.S.G. et al A rare and reversible case of heart failure: Hypocalcemia due to hypoparathyroidism. Clin Case Rep. 2019; 7(10): 1932–34. https://dx.doi.org/10.1002/ccr3.2397.
- Parepa I., Mazilu L., Suceveanu A. et al. Hypocalcemic cardiomyopathy: A rare heart failure etiology in adult. Acta Endocrinol (Buchar). 2019; 5(1): 107–12. https://dx.doi.org/10.4183/aeb.2019.107.
- Kalinowski L., Dobrucki L.W., Malinski T. Nitric oxide as a second messenger in parathyroid hormone-related protein signaling. J Endocrinol. 2001; 170(2): 433–40. https://dx.doi.org/10.1677/joe.0.1700433.
- Bansal B., Bansal M., Bajpai P. et al. Hypocalcemic cardiomyopathy: Different mechanisms in adult and pediatric cases. J Clin Endocrinol Metab. 2014; 99(8): 2627–32. https://dx.doi.org/10.1210/jc.2013-3352.
- Shoback D.M., Bilezikian J.P., Costa A.G. et al. Presentation of hypoparathyroidism: Etiologies and clinical features. J Clin Endocrinol Metab. 2016; 101(6): 2300–12. https://dx.doi.org/10.1210/jc.2015-3909.
- Kim S.H., Rhee Y., Kim Y.M. et al Prevalence and complications of nonsurgical hypoparathyroidism in Korea: A nationwide cohort study. PLoS One. 2020; 15(5): e0232842. https://dx.doi.org/10.1371/journal.pone.0232842.
- Gosmanova E.O., Chen K., Ketteler M. et al. Risk of cardiovascular conditions in patients with chronic hypoparathyroidism: A retrospective cohort study. Adv Ther. 2021; 38(8): 4246–57. https://dx.doi.org/10.1007/s12325-021-01787-7.
- Solzbach U., Kitterer H.R., Haas H. Reversible congestive heart failure in severe hypocalcemia. Herz. 2010; 35(7): 507–10.
- https://dx.doi.org/10.1007/s00059-010-3374-7.
Arquivos suplementares
