Metal nano- and microparticles-induced oral mucosa immunopathological inflammation
- 作者: Labis V.V.1, Bazikyan E.A.1, Sizova S.V.2, Khaidukov S.V.2, Zhigalina O.M.3, Khmelenin D.N.3, Dyachkova I.G.3, Zolotov D.A.3, Asadchikov V.E.3, Isakina M.O.4, Gildeeva G.N.4, Kozlov I.G.4
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隶属关系:
- Russian University of Medicine of the Ministry of Healthcare of Russia
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry of RAS
- National Research Center “Kurchatov Institute”
- I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)
- 期: 卷 10, 编号 2 (2024)
- 页面: 78-91
- 栏目: CL INICAL CASE
- URL: https://journals.eco-vector.com/2412-4036/article/view/631833
- DOI: https://doi.org/10.18565/therapy.2024.2.78-91
- ID: 631833
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详细
Studies of the causes and mechanisms of development of oral mucosa chronic inflammation must be carried out taking into account immunological and nanotechnological aspects that fully reflect the picture of cause-effect relations.
The aim: To analyze a clinical case to verify the cause-effect relations in the pathogenesis of idiopathic immunopathological inflammation of oral mucosa induced by metal nano- and microparticles (NMMPs).
Material and methods. In order to verify the main diagnosis in patient Zh., 80 years old, after complex implantological treatment (at the age of 70 years) and the appearance of the first clinical signs of idiopathic immunopathological chronic inflammation of the oral mucosa, clinical and laboratory studies were performed, which made it possible to identify a new etiopathogenetic link of cause-effect relations of arisen complications. During surgical revisions of the area of previously installed dental implants and metal bar structures, histology of biopsy samples of the oral mucosa and bone structures was performed to identify impregnated NMMPs into the structure of pathologically changed tissues. In addition, a basophil test was performed for the presence of delayed-type hypersensitivity with NMMPs-containing supernatants obtained from the surface of the bar structure and dental implants.
Results. The identity of metal NMMPs that impregnated pathological tissue areas with the presence of a chronic inflammatory process and supernatants obtained from the surface of medical devices in laboratory conditions, which were previously installed in the patient’s oral cavity, was found. No delayed allergic reaction to nano-sized particles was fixed.
Conclusion. One of the reasons for oral mucosa chronic autoinflammation occurrence may be the emission and accumulation of metal NMMRs from the surface of medical alloys used in the oral cavity of patients.
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作者简介
Varvara Labis
Russian University of Medicine of the Ministry of Healthcare of Russia
编辑信件的主要联系方式.
Email: varvara2001@mail.ru
ORCID iD: 0000-0001-7632-3234
MD, PhD (Medicine), associate professor of the Department of propaedeutics of surgical dentistry
俄罗斯联邦, 127473, Moscow, 20/1 Delegatskaya St.Ernest Bazikyan
Russian University of Medicine of the Ministry of Healthcare of Russia
Email: prof.bazikian@gmail.com
ORCID iD: 0000-0002-9184-3737
MD, Dr. Sci. (Medicine), head of the Department of propaedeutics of surgical dentistry, professor, dean of highly qualified personnel training
俄罗斯联邦, 127473, Moscow, 20/1 Delegatskaya St.Svetlana Sizova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry of RAS
Email: sv.sizova@gmail.com
ORCID iD: 0000-0003-0846-4670
MD, PhD (Chemistry), researcher at the Department of molecular biophysics
俄罗斯联邦, 117997, Moscow, 16/10 Miklouho-Maklaya St.Sergey Khaidukov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry of RAS
Email: khsergey54@mail.ru
ORCID iD: 0000-0003-1600-5335
MD, Dr. Sci. (Biology), senior researcher at the Department of carbohydrates
俄罗斯联邦, 117997, Moscow, 16/10 Miklouho-Maklaya St.Olga Zhigalina
National Research Center “Kurchatov Institute”
Email: zhigal@crys.ras.ru
ORCID iD: 0000-0003-4721-4105
MD, Dr. Sci. (Physics and Mathematics), leading researcher
俄罗斯联邦, 123182, Moscow, 1 Akademika Kurchatova Sq.Dmitrii Khmelenin
National Research Center “Kurchatov Institute”
Email: xorrunn@gmail.com
ORCID iD: 0000-0003-0894-5087
MD, PhD (Physics and Mathematics), researcher
俄罗斯联邦, 123182, Moscow, 1 Akademika Kurchatova Sq.Irina Dyachkova
National Research Center “Kurchatov Institute”
Email: dyachkova.i@crys.ras.ru
ORCID iD: 0000-0001-7615-6878
MD, PhD (Physics and Mathematics), senior researcher
俄罗斯联邦, 123182, Moscow, 1 Akademika Kurchatova Sq.Denis Zolotov
National Research Center “Kurchatov Institute”
Email: zolotovden@crys.ras.ru
ORCID iD: 0000-0003-3701-9517
MD, PhD (Physics and Mathematics), senior researcher
俄罗斯联邦, 123182, Moscow, 1 Akademika Kurchatova Sq.Victor Asadchikov
National Research Center “Kurchatov Institute”
Email: asad@crys.ras.ru
ORCID iD: 0000-0003-3602-7582
MD, Dr. Sci. (Physics and Mathematics), chief researcher
俄罗斯联邦, 123182, Moscow, 1 Akademika Kurchatova Sq.Maria Isakina
I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)
Email: mery.isakina8@mail.ru
ORCID iD: 0009-0008-3764-5941
5th year student of N.F. Filatov Clinical Institute of Child Health
俄罗斯联邦, 119435, Moscow, 19/1 Bol’shaya Pirogovskaya St.Gelia Gildeeva
I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)
Email: gildeeva_g_n@staff.sechenov.ru
ORCID iD: 0000-0002-2537-2850
MD, Dr. Sci. (Medicine), professor, head of the Department of organization and management in the field of drug circulation
俄罗斯联邦, 127018, Moscow, 1/17 Skladochnaya St.Ivan Kozlov
I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov University)
Email: immunopharmacology@yandex.ru
MD, Dr. Sci. (Medicine), professor, professor of the Department of organization and management in the field of drug circulation
俄罗斯联邦, 127018, Moscow, 1/17 Skladochnaya St.参考
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