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CITRUS PECTIN COMPLEXES WITH NIFEDIPINE: PREPARATION AND PHYSICOCHEMICAL PROPERTIES
- Authors: Minzanova S.T.1, Chekunkov E.V.1, Khabibullina A.V.1, Arkhipova D.M.1, Mironova L.G.1, Hamatgalimov A.R.1, Milyukov V.A.1, Mironov V.F.1
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Affiliations:
- Arbuzov Institute of Organic and Physical Chemistry, “Kazan Scientific Center of Russian Academy of Sciences”
- Issue: Vol 508, No 1 (2023)
- Pages: 103-110
- Section: PHYSICAL CHEMISTRY
- URL: https://journals.eco-vector.com/2686-9535/article/view/651999
- DOI: https://doi.org/10.31857/S2686953523700176
- EDN: https://elibrary.ru/EWGPLY
- ID: 651999
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Abstract
The formation of stable complexes of pectin polysaccharides with the hypotensive drug “Nifedipine” was confirmed by IR and UV spectroscopy, their stoichiometry was determined and the conditions of their production were optimized. Peculiarities of thermal decomposition of pectin and synthesized complexes with nifedipine were studied by TGA/DSC method. The results obtained are a scientific basis for the creation of a new water-soluble non-toxic dosage form of nifedipine, which will significantly expand the use of the drug in medicine.
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About the authors
S. T. Minzanova
Arbuzov Institute of Organic and Physical Chemistry, “Kazan Scientific Center of Russian Academy of Sciences”
Author for correspondence.
Email: minzanova@iopc.ru
Russian Federation, 420111, Kazan
E. V. Chekunkov
Arbuzov Institute of Organic and Physical Chemistry, “Kazan Scientific Center of Russian Academy of Sciences”
Email: minzanova@iopc.ru
Russian Federation, 420111, Kazan
A. V. Khabibullina
Arbuzov Institute of Organic and Physical Chemistry, “Kazan Scientific Center of Russian Academy of Sciences”
Email: minzanova@iopc.ru
Russian Federation, 420111, Kazan
D. M. Arkhipova
Arbuzov Institute of Organic and Physical Chemistry, “Kazan Scientific Center of Russian Academy of Sciences”
Email: minzanova@iopc.ru
Russian Federation, 420111, Kazan
L. G. Mironova
Arbuzov Institute of Organic and Physical Chemistry, “Kazan Scientific Center of Russian Academy of Sciences”
Email: minzanova@iopc.ru
Russian Federation, 420111, Kazan
A. R. Hamatgalimov
Arbuzov Institute of Organic and Physical Chemistry, “Kazan Scientific Center of Russian Academy of Sciences”
Email: minzanova@iopc.ru
Russian Federation, 420111, Kazan
V. A. Milyukov
Arbuzov Institute of Organic and Physical Chemistry, “Kazan Scientific Center of Russian Academy of Sciences”
Email: minzanova@iopc.ru
Russian Federation, 420111, Kazan
V. F. Mironov
Arbuzov Institute of Organic and Physical Chemistry, “Kazan Scientific Center of Russian Academy of Sciences”
Email: minzanova@iopc.ru
Russian Federation, 420111, Kazan
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