THE CHARACTER OF SYSTEMIC CHANGES IN ADAPTIVE AND INNATE IMMUNE RESPONSE IN PATIENTS WITH MULTIPLE SCLEROSIS

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Abstract

The article presents the results of a comprehensive analysis of the parameters of innate and adaptive immunity in 85 patients with recurrent remitting multiple sclerosis (MS) with its exacerbation (54 people) and in conditions of persistent clinical remission (31 people). It is shown the signs of autoinflammation and increased reactivity of the T-link of adaptive immunity to be registered not only in exacerbation, but also in remission. The revealed changes determine the pathogenetic basis of MS progression and they should be taken into account when accompanying patients in remission to prevent clinical activation.

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About the authors

I I Andreeva

Rostov State Medical University, Rostov-on-Don

L P Sizyakina

Rostov State Medical University, Rostov-on-Don

Z A Goncharova

Rostov State Medical University, Rostov-on-Don

References

  1. Christophi GP, Gruber RC, Panos M, et al. Interleukin-33 upregulation in peripheral leukocytes and CNS of multiple sclerosis patients. Clin. Immunol. 2012;142(3):308-319.
  2. Andreeva II, Sizyakina LP, Goncharova ZA. Inversion of the homeostatic properties of the immune system in multiple sclerosis. Medical Bulletin of the South of Russia. 2016;2:23-27.
  3. Martinez NE, Karlsson F, Sato F, et al. Protective and Detrimental Roles for Regulatory T Cells in a Viral Model for Multiple Sclerosis. Brain Pathol. 2014;24(5):436-451.
  4. Mc Donald WI, Compston A, Edan G, et al. Recommended Diagnostic Criteria for Multiple Sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis. Ann Neurol. 2001;50:121-127.

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Copyright (c) 2019 Andreeva I.I., Sizyakina L.P., Goncharova Z.A.

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 74760 от 29.12.2018 г.