ESPECIALLY CELLULAR IMMUNITY IN PATIENTS WITH TRAUMATIC BRAIN INJURY OF DIFFERENT SEVERITY IN ACUTE PERIOD

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Abstract

Currently, it is known that in response to brain damage a reaction from the immune system is triggered, but its role in the formation of clinical manifestations remains a little-studied problem to date. Using multicolor cytometric analysis, a study was conducted to determine the number of Th1-, Th2-, Tfh- and Th17-cells among CD45RA-negative CD3+CD4+ cells in a group of patients with mild TBI (M-TBI, n = 20) and with moderate to severe TBI (MS-TBI, n = 16) and a group of conditionally healthy donors (n = 30). The imbalance between Th2 cells and Th17 cells was found in patients with TBI in the acute period, which probably predetermines the course of the disease and the development of complications.

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A O Norka

Pavlov First Saint Petersburg State Medical University, Saint Petersburg

R N Kuznetsova

Pavlov First Saint Petersburg State Medical University, Saint Petersburg; Saint Petersburg Pauster Institute, Saint Petersburg

S V Kudryavtsev

Pavlov First Saint Petersburg State Medical University, Saint Petersburg; Institute of Experimental Medicine, Saint Petersburg

S N Kovalenko

S.M. Kirov Military Medical Academy, Saint Petersburg; City Hospital No. 26, Saint Petersburg

M K Serebriakova

Institute of Experimental Medicine, Saint Petersburg

S V Vorobyev

Saint Petersburg State Pediatric Medical University, Saint Petersburg

References

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  2. Celia A. McKee and John R. Lukens. T cells in the central nervous system: messengers of destruction or purveyors of protection? Immunology. 2014;(141):340-344.
  3. O’Neil ME, Carlson K, Storzbach D, et al. Complications of Mild Traumatic Brain Injury in Veterans and Military Personnel: A Systematic Review. Washington (DC): Department of Veterans Affairs (US); 2013 Jan.
  4. Kudryavtsev IV, Borisov AG, Krobinets II, et al. Chemokine receptors at distinct differentiation stages of T-helpers from peripheral blood. Medical Immunology (Russia). 2016;18(3):239-250.

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Copyright (c) 2019 Norka A.O., Kuznetsova R.N., Kudryavtsev S.V., Kovalenko S.N., Serebriakova M.K., Vorobyev S.V.

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