CHARACTERISTICS OF ADAPTATIONAL REACTIONS AND MALIGNANT SPREAD IN TUMORS OF VARIOUS LOCATIONS

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Abstract

The character, intensity and quantitative indicator (QI) of general nonspecific adaptational reactions (AR) of the body were studied in patients with lung cancer (LC) or biliopancreatoduodenal cancer (BPDC) with various malignant spread. Poor AR characteristics were associated with the presence of metastases, but did not depend on the surgery volume. AR QI significantly differed depending on the metastatic status in patients with resectable LC receiving similar surgery treatment. AR QI in BPDC patients a day after radical pancreatoduodenal resection was higher than after bypass anastomosis. Thus, the studied AR characteristics demonstrated the state of systemic neuroimmune mechanisms of the nonspecific antitumor resistance of the body.

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G V Zhukova

Rostov Research Institute of Oncology

A I Shikhlyarova

Rostov Research Institute of Oncology

U M Gaziev

Rostov Research Institute of Oncology

M S Zinkovich

Rostov Research Institute of Oncology

A V Snezhko

Rostov Research Institute of Oncology

Yu N Lazutin

Rostov Research Institute of Oncology

A N Shevchenko

Rostov Research Institute of Oncology

M I Bragina

Rostov Research Institute of Oncology

A I Zhadobina

Rostov Research Institute of Oncology

References

  1. Garkavi LKh. Activation therapy. Rostov-on-Don. 2006. 256 p. (In Russ.)
  2. Selye H. Thymus and adrenals in the response of the organisms to injuries and intoxication. Brit. J. Exp. Path. 1936;17:234-248.
  3. Zhukova GV, Shikhlyarova AI, Maschenko NM, et al. Processes in regulatory systems during development of various adaptational reactions and evaluation of functional state dynamics in the organism. Cardio¬metry. 2015;7:47-57.

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Copyright (c) 2019 Zhukova G.V., Shikhlyarova A.I., Gaziev U.M., Zinkovich M.S., Snezhko A.V., Lazutin Y.N., Shevchenko A.N., Bragina M.I., Zhadobina A.I.

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