The relevance of cytokine indicators in the hemorrhagic transformation development of cerebral infarction risk measuring

The purpose of this research is to study the prognostic role of cytokines in plasma in patients with cerebral infarction while assessing the risk of hemorrhagic transformation.Materials and methods. Three groups of patients were identified. Group 1: 66 patients with cerebral infarction without hemorrhagic transformation (CI without HT), mean age 63.9 ± 1.3 years. Group 2: 27 patients with cerebral infarction and with hemorrhagic transformation (CI with HT), mean age was 65.9 ± 2.5 years. Group 3: 65 patients with cerebral hemorrhage (CH), average age - 58.8 ± 1.6 years. The plasma cytokines concentration measurement (IL-1β, TNF-α, IL-6, IL-8, IFN-γ, IL-1Ra, IL-10, IL-4) was performed on the 1st, 2nd and 10th days after the stroke manifestation. The control group - 55 donors cytokines indicators.Results. In the CI with HT group, compared with the CI without HT group and the CH group, the lowest levels of IL-1β and TNF-α were detected on the 1st, 2nd and 10th day since the disease symptoms, and, conversely, the highest IL-1Pa values were revealed on the 1st and 2nd days; IL-4 values - on the 1st and 10th days (p < 0.05). The high HT development risk factors on the 1st day of the disease symptoms are IL-6 ≥ 46.6 pg/ml, IL-8 ≥ 14.7 pg/ml, IL-10 ≥ 12.1 pg/ml, IL-4 ≥ 7.6 pg/ml. In contrast, IL-1β ≥ 1.9 pg/ml, TNF-α ≥ 14.4 pg/ml indicate a low probability of HT development.Conclusion. Predictors of the CI HT development risk on the 1st day of the disease are plasma cytokines indicators IL-1β, TNF-α, IL-6, IL-8, IL-10, IL-4.

hemorrhagic transformation, cerebral infarction risk, cerebral infarction, cytokines