THE DEVELOPMENT OF NEUROINFLAMMATORY PROCESSES IN RATS IN EARLY POSTNATAL ONTOGENESIS AFTER PRENATAL HYPERHOMOCYSTEINEMIA

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Abstract

Prenatal exposure to high levels of homocysteine has long-term impact on growth retardation of nervous system development and is related to central nervous system diseases in children. However, it is not well-characterized whether gestational exposure to hyperhomocysteinemia (HHC) affects the development of nervous system in offspring. It was observed disturbed neuroblast generation and migration, neuronal death in cortex, revealed as reduction of pyramidal neurons number, and activation of glia in the month after birth in offspring subjected to HHC. These disorders may be associated with changes in the content of pro-inflammatory cytokines in the cortex tissue of HHC pups.

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A D Shcherbitskaia

I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of Sciences, Saint Petersburg; The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott, Saint Petersburg

D S Vasilev

I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of Sciences, Saint Petersburg

N L Tumanova

I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of Sciences, Saint Petersburg

Ju P Milyutina

The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott, Saint Petersburg

I V Zalozniaia

The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott, Saint Petersburg

A V Arutjunyan

The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott, Saint Petersburg

References

  1. Vasilev DS, Dubrovskaya NM, Tumanova NL, Zhuravin IA. Prenatal Hypoxia in Different Periods of Embryogenesis Differentially Affects Cell Migration, Neuronal Plasticity, and Rat Behavior in Postnatal Ontogenesis. Front Neurosci. 2016;31(10):126.
  2. Shcherbitskaya AD, Milyutina YuP, Zaloznyaya IV, et al. The Effects of Prenatal Hyperhomocysteinemia on the Formation of Memory and the Contents of Biogenic Amines in the Rat Hippocampus. Neurochemical Journal. 2017;11(4):296-301.
  3. Rakic P. Specification of cerebral cortical areas. Science. 1988;241:170-176.
  4. Kraft AD, Harry GJ. Features of microglia and neuroinflammation relevant to environmental exposure and neurotoxicity. Int J Environ Res Public Health. 2011;8:2980-3018.

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Copyright (c) 2019 Shcherbitskaia A.D., Vasilev D.S., Tumanova N.L., Milyutina J.P., Zalozniaia I.V., Arutjunyan A.V.

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