Email this article 
Effective combinations of silver nanoparticles and antimicrobial peptides against antibiotic-resistant bacteria
- Authors: Vladimirova E.1
-
Affiliations:
- Institute of Experimental Medicine
- Section: Original research
- URL: https://journals.eco-vector.com/MAJ/article/view/630076
- DOI: https://doi.org/10.17816/MAJ630076
- ID: 630076
Cite item
Full Text
Abstract
The problem of constantly growing resistance of microorganisms to used antibiotics forces scientists to constantly search for new antimicrobial agents. We have carried out a comparative assessment of the antibacterial activity and toxicity of silver nanoparticles stabilized by various substances and antimicrobial peptides with a β-hairpin structure, and also investigated their combined antimicrobial action. We have identified effective combinations of silver nanoparticles and antimicrobial peptides that act synergistically against antibiotic-resistant strains of bacteria, that is, they repeatedly enhance each other’s effect.
Full Text
About the authors
Elizaveta Vladimirova
Institute of Experimental Medicine
Author for correspondence.
Email: vladymyrovaliza18@mail.ru
ORCID iD: 0000-0002-6576-9844
Russian Federation
References
- Panteleev PV, Myshkin MY, Shenkarev ZO, Ovchinnikova TV. Dimerization of the antimicrobial peptide arenicin plays a key role in the cytotoxicity but not in the antibacterial activity. Biochemical and biophysical research communications. 2017; 482(4):1320-1326. doi: 10.1016/j.bbrc.2016.12.035
- Eliseev I.E., Smetanin R.V., Shamova O.V., Klimov N.A., Komlev A.S., Sukhareva M.S., Vladimirova E.V., Zharkova M.S. Artamonov A.Yu., Orlov D.S. Synthetic analogues of natural peptides with antimicrobial activity. Patent application for invention No. 2023132474 dated 04.12.2023.
- Shafer WM. (ed.). Antibacterial peptide protocols. Totowa, NJ, USA: Humana Pres; 1997. Vol. 78. 255 p.
- Orhan G, Bayram A, Zer Y, Balci I. Synergy tests by E test and checkerboard methods of antimicrobial combinations against Brucella melitensis. Journal of clinical microbiology. 2005; 43(1): 140-143. doi: 10.1128/jcm.43.1.140-143.2005
- Chatterjee T, Chatterjee BK, Majumdar D, Chakrabarti P. Antibacterial effect of silver nanoparticles and the modeling of bacterial growth kinetics using a modified Gompertz model. Biochim Biophys Acta. 2015; 1850(2): 299–306. doi: 10.1016/j.bbagen.2014.10.022
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).