Email this article MODELING OF LONG-TERM EFFECTS OF POISONING CAUSED BY EXPOSURE TO NEUROTOXICANTS (LITERATURE REVIEW)
- Authors: Potapov P.K.1, khasanov I.I.2, Shustov E.B.1, Kotkin S.A.2, Markin I.V.2
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Affiliations:
- ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ БЮДЖЕТНОЕ УЧРЕЖДЕНИЕ "НАУЧНО-КЛИНИЧЕСКИЙ ЦЕНТР ТОКСИКОЛОГИИ ИМЕНИ АКАДЕМИКА С.Н. ГОЛИКОВА ФЕДЕРАЛЬНОГО МЕДИКО-БИОЛОГИЧЕСКОГО АГЕНТСТВА"
- ФГАУ "Военный инновационный технополис "ЭРА"
- Section: Analytical reviews
- Published: 15.11.2024
- URL: https://journals.eco-vector.com/MAJ/article/view/631869
- DOI: https://doi.org/10.17816/MAJ631869
- ID: 631869
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Abstract
the problem of long-term consequences of acute poisoning with neurotoxicants is relevant in industrial hygiene and toxicology, as it affects not only biomedical issues, but also socio-legal aspects. This problem has been and is being given great importance both in Russia and abroad. The authors devoted the main attention in their research to the acute period of intoxication. However, in recent years, scientific research has been actively conducted to study the neurotoxic effect of toxicants in the long-term period of intoxication, as well as the search for effective therapies for these disorders. It can be assumed that the long-term consequences of acute severe poisoning with neurotoxicants are explained by the disruption of various adaptation mechanisms and the launch of a cascade of pathological reactions. Existing studies of the mechanisms of formation of long-term consequences of poisoning with neurotoxic substances do not provide a definitive answer about the pathogenesis of emerging disorders.
One of the approaches to understanding the complex mechanisms of the development of pathological processes in the body is experimental modeling. Without the creation of biomodels, practical medicine will never make progress and will not be scientifically sound. The review examines the experience of modeling the long-term effects of intoxication in case of poisoning with neurotoxicants.
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About the authors
Petr Kirillovich Potapov
ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ БЮДЖЕТНОЕ УЧРЕЖДЕНИЕ "НАУЧНО-КЛИНИЧЕСКИЙ ЦЕНТР ТОКСИКОЛОГИИ ИМЕНИ АКАДЕМИКА С.Н. ГОЛИКОВА ФЕДЕРАЛЬНОГО МЕДИКО-БИОЛОГИЧЕСКОГО АГЕНТСТВА"
Author for correspondence.
Email: FORWARDspb@mail.ru
ORCID iD: 0000-0002-4602-4468
SPIN-code: 5979-4490
Кандидат медицинских наук, старший научный сотрудник лаборатории лекарственной токсикологии
Russian Federation, 192019,г. Санкт-Петербург, улица Бехтерева, д. 1Ilnar Ildarovich khasanov
ФГАУ "Военный инновационный технополис "ЭРА"
Email: FORWARDspb@mail.ru
ORCID iD: 0000-0002-0327-0343
оператор научной роты
Russian Federation, 353456, Краснодарский край, Анапский район, город Анапа, Пионерский пр-кт, д. 41Evgeniy Borisovich Shustov
ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ БЮДЖЕТНОЕ УЧРЕЖДЕНИЕ "НАУЧНО-КЛИНИЧЕСКИЙ ЦЕНТР ТОКСИКОЛОГИИ ИМЕНИ АКАДЕМИКА С.Н. ГОЛИКОВА ФЕДЕРАЛЬНОГО МЕДИКО-БИОЛОГИЧЕСКОГО АГЕНТСТВА"
Email: FORWARDspb@mail.ru
ORCID iD: 0000-0001-5895-688X
главный научный сотрудник
Russian Federation, 192019, город Санкт-Петербург, ул. Бехтерева, д.1Sergey Aleksandrovich Kotkin
ФГАУ "Военный инновационный технополис "ЭРА"
Email: FORWARDspb@mail.ru
ORCID iD: 0009-0006-7995-6559
оператор научной роты
Russian Federation, 353456, Краснодарский край, Анапский район, город Анапа, Пионерский пр-кт, д. 41Ilya Vladimirovich Markin
ФГАУ "Военный инновационный технополис "ЭРА"
Email: FORWARDspb@mail.ru
ORCID iD: 0000-0001-8016-0693
кандидат технических наук, старший научный сотрудник научно-исследовательского отдела
Russian Federation, 353456, Краснодарский край, Анапский район, город Анапа, Пионерский пр-кт, д. 41References
Supplementary files
Note
the problem of long-term consequences of acute poisoning with neurotoxicants is relevant in industrial hygiene and toxicology, as it affects not only biomedical issues, but also socio-legal aspects. This problem has been and is being given great importance both in Russia and abroad. The authors devote the main attention in their research to the acute period of intoxication. However, in recent years, scientific research has been actively conducted to study the neurotoxic effect of toxicants in the long-term period of intoxication, as well as the search for effective therapies for emerging health disorders. It can be assumed that the consequences of acute poisoning with neurotoxic substances in the long term are explained by the disruption of various adaptation mechanisms and the launch of a cascade of pathological reactions. Existing studies of the mechanisms of formation of long-term consequences of poisoning with neurotoxic substances do not provide a definitive answer about the pathogenesis of emerging disorders.
The use of experimental modeling is one of the methods of studying the pathogenesis of various conditions. Without this approach, the development of practical medicine is impossible. The review examines the experience of modeling the long-term effects of intoxication in case of poisoning with neurotoxicants.
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