Evolution of the cholesterol concept of atherogenesis from Anichkov up to now

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Abstract

The review describes the development of cholesterol concept of atherogenesis from the classical investigations of Anichkov and Khalatov [1913], who induced experimental cholesterol atherosclerosis in rabbits, to the present time. The authors of the review have made a conclusion that the cholesterol concept of atherogenesis has not lost its significance on the background of the contemporary data about the presence in blood of different classes of lipoproteins, including antiatherogenic, about participation in atherogenesis of peroxidatively modified low density lipoproteins, of various blood and vessel wall cells, and in addition, of a large number of other factors. What is more, the cholesterol lowering therapy keeps the leading place in the primary and secondary prevention of coronary heart disease events and other clinical manifestations of atherosclerosis, and also in their treatment.

About the authors

A. N. Кlimov

Research Institute of Experimental Medicine of the Russian Academy of Medical Sciences

Author for correspondence.
Email: shabanov@mail.rcom.ru

академик РАМН

Russian Federation, Saint Petersburg

V. A. Nagornev

Research Institute of Experimental Medicine of the Russian Academy of Medical Sciences

Email: shabanov@mail.rcom.ru

академик РАМН

Russian Federation, Saint Petersburg

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