Role of brain adrenergic systems in increasing activity of sympathetic nervous system in experimental hypertension

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Abstract

Hemodynamic parameters in hypertensive rats with different genesis of hypertension were compared initially and under agonist and antagonist of 62A-adrenoreceptors clonidine and yohimbine influence. Were used two models of hypertension - SHR and DOCA-salt hypertension (DOCA). Initially they had comparative blood pressure (BP), intersystolic interval (ISI) and arterial baroreflex value (AB). After administration of clonidine were observed ISI increase and BP decrease. Administration of yohimbine (antagonist of 62A-adrenore- ceptors) leads to different effects in two groups - in SHR BP did not change, in DOCA there was significant BP decrease. Based on our results we suggest that mechanism of symphathetic hyperactivity is different in these models of hypertension.

About the authors

N. A. Feldsherova

V.A. Almazov Research Institute of Cardiology; I.R Pavlov State Medical University

Author for correspondence.
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg; St. Petersburg, 197022

R. S. Khrustaleva

V.A. Almazov Research Institute of Cardiology; I.R Pavlov State Medical University

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg; St. Petersburg, 197022

V. A. Tsyrlin

V.A. Almazov Research Institute of Cardiology; I.R Pavlov State Medical University

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg; St. Petersburg, 197022

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