PIA1/A2 gene polymorphism of platelet receptor IIb/IIIa and platelet aggregation activity in men after myocardial infarction occurred at an early age

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Abstract

We examined 212 men after myocardial infarction (MI) occurred before the age of 45, and 198 healthy men (control group). During the 2-year period 23 patients died of recurrent Ml.

Platelet aggregation was studied by G. V. R. Born’s and D. R. O’Brien’s method, PIA1/A2 glycoprotein (GP) IIb/IIIa gene polymorphism - by polymerase chain reaction (PCR) and subsequent restriction according to P. J. Neuman’s et al. method, plasma lipids - by enzymatic calorimetric method.

The level of PIA2 allele of GP IIb/IIIa was significantly higher in the study group than among controls (30,0 and 21,0 %, respectively; p=0,03). Among the dead patients the rate of PIA2 allele was significantly higher than among other patients (0,24 and 0,15, respectively; p=0,02). Maximal velocity of platelets aggregation was also higher in the patients with PIA2/A2 genotype than in those with PIA1 allele.

We conclude that the risk of MI in young men as well as the risk of sudden death of recurrent MI is higher in those with PIA2 allele of GP IIb/IIIa gene. This could be due to changes in platelet aggregation in patients with various genotypes of GP IIb/IIIa gene.

About the authors

O. A. Berkovich

State Medical University

Author for correspondence.
Email: medaj@eco-vector.com
Russian Federation, St. Petersburg

E. A. Bazhenova

State Medical University

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg

O. V. Sirotkina

Institute of Nuclear Physics RAS

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg

D. V. Cherkashin

Russian Military-Medical Academy

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg

S. A. Boitsov

Russian Military-Medical Academy

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg

E. V. Shlyakhto

State Medical University

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg

E. I. Schwartz

Institute of Nuclear Physics RAS

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg

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