The experience of aerosol application of the combined preparation of interferon with «Olifen» in complex therapy of influenza complicated by pneumonia

A study of therapeutic efficiency and tolerance of a recombinant interferon (IFN) in a combination with antioxidant «Olifen» was carried out at aerosol inhalation by the patients with complicated forms of influenza. A single dose was 0,5 mln. ME of IFN preparation and 0,14 g of olifen. The combined preparation was clinically tested on 37 patients divided into 4 groups: 1 group - basic therapy + aerosol interferon with olifen; 2 - basic therapy + aerosol IFN without olifen; 3 - basic therapy + intramuscular interferon; 4 - basic therapy + normal saline aerosol. The efficiency of the combined preparation aerosol application was estimated by clinical and laboratory parameters in dynamics. The results of clinical study of the IFN and olifen preparation have demonstrated the following: 1. The combined application of IFN with olifen positively influences the dynamics of the basic clinical symptoms, which conducted to a reduction of disease duration. 2. The combined preparation aerosol application accelerates the normalization of peripheral blood parameters (leukocytosis, lymphocytosis, ESR) and the normalization of external respiration function. 3. The aerosol application was not accompanied by side-effects. Thus, the combined application of IFN with olifen as respirable aerosol is more effective in treatment of the complicated forms of influenza than the aerosol and intramuscular application of IFN alone.