Immune status in teenagers with bronchial asthma in Velikii Novgorod

Twenty teenagers with bronchial asthma underwent immunologic examinations. The level expression of differentiation markers of lymphocyte such as CD 3⁺, CD 3⁺ CD 4^+, CD 3⁺ CD 8^+, CD 8^+, CD 3^- CD 16 & CD 56*, CD 19⁺, CD 19⁺ CD 23⁺, CD20⁺ CD 5⁺, CD 20⁺ CD 5^-, CD 3⁺ CD 25⁺, CD 4⁺ CD62 L⁺, CD 3⁺ CD4⁺CD25⁺, CD 3⁺ TC Rab^- was studied. A comparative analysis of immunological parameters showd, in teenagers with bronchial asthma versus healthy teenagers, the condition of immunity to be characterized by the changing expression of lymphocyte antigens. A lower level of CD 20⁺ CD 5⁺ and CD 19⁺ CD 62L cells, and a higher content of CD 20⁺ CD 5^- lymphocytes were observed in patients with bronchial asthma. We have investigated the content of lactoferrin and Ig E in the blood of 10 healthy persons and in that of 20 teenagers ill with bronchial asthma. Patients with bronchial asthma have the investigated indicer virtually increased. In healthy teenagers noticed significant changes of IgE and LF levels that are often higher that normal common indices allow to speak about unfavourable effect of environment on the body. An evaluation of the quantitative parameters of immunity in patients with bronchial asthma can be used in working out the immunological and prognostic criteria for the disease progression.