Influence of sucrose and saccharin on primary-reinforcing effect of ethanol in DBA/2 mice

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The primary reinforcing properties of ethanol using intravenous self-administration technique have been studied in drug-naive DBA/2 mice, known as alcohol-avoiding strain. The optimal ethanol concentration produced the maximal operant output is 2% v/v. Suppression of ethanol self-administration after 0,1% saccharin or 30% sucrose intake demonstrates the role of sweet substances as alternative non-drug reinforcers.

About the authors

M. V. Tsoy

I. P. Pavlov State Medical University

Author for correspondence.
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg, 197089

N. A. Patkina

I. P. Pavlov State Medical University

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg, 197089

References

  1. Bachmanov A. A., Reed D. R., Tordoff M. G., Price R. A., Beachamp G. K. Intake of ethanol, sodium chloride, sucrose, citric acid and quinine hydrochloride solutions by mice: a genetic ana-lysis // Behavior. Genetics. 1996. Vol. 26. P. 563-573.
  2. Belknap J. K., Crabbe J. C., Young E. R. Voluntary consumption of ethanol in 15 inbred mouse strains // Psychopharmacol. 1993. Vol. 112. P. 503-510.
  3. Bergmann E., Lieblich I., Cohen E., Ganchrow J. R. Influence on intake of sweet solutions on the analgesic effect of a low dose of morphine in randomly bred rats // Behavioral and Neural Biology. 1985. Vol. 44. P. 347-353.
  4. Brown R. V. and Hutcheson D. P. Nutrition and alcohol consumption in Sinclair miniature pig // Quarterly Jour. of Studies on Alcohol. 1973. Vol. 34. P. 758-763.
  5. Carroll M. E. Concurrent phencyclidine and saccharin access: presentation of an alternative reinforcer reduces drug intake // J. Exp. Anal. Behav. 1985. Vol. 43. P. 131-144.
  6. Carroll M. E., Lac S. T., Nygaard S. L. A concurrently available nondrug reinforcer prevents the aquisition or reduces the maintenance of cocainereinforced behavior // Psychopharmacol. 1989. Vol. 97. P. 23-29.
  7. Forsander O. A., Sinclair J. D. Protein, carbohydrate and ethanol consumption: interaction in AA and ANA rats // Alcohol. 1988. Vol. 5. P. 233-238.
  8. Froehlich J. C, Li T.-K. Opioid involvement in alcohol drinking. Annals of the New York Academy of Sciences. 1994. Vol. 739. P. 156-167.
  9. George F. R. Genetic and environmental factors in ethanol self-administration // Pharm. Biochem. Behav. 1987. Vol. 27. P. 379-384.
  10. Gosnell B. A., Krahn D. D. The relationship between saccharin and alcohol intake in rats // Alcohol. 1992. Vol. 9. P. 203-206.
  11. Grahame N. J., Cunningham C. L. Intravenous ethanol self-administration in C57BL/6J and DBA/2J mice // Alcohol. Clin. Exp. Res. Feb. 1997. Vol. 21(1). P. 56-62.
  12. Kampov-Polevoy A. B., Kasheffskaya О. P. and Sinclair J. D. Initial acceptance of ethanol: gustatory factors and patterns of alcohol drinking // Alcohol. 1990. Vol. 7. P. 83-85.
  13. Kampov-Polevoy A. B., Overstreet D. H., Rezvani A. H. and Janowsky D. S. Supression of ethanol intake in alcohol-preferring rats by prior voluntary saccharin consumption // Pharm. Biochem. Behav. 1995. Vol. 52. P. 59-64.
  14. Kampov-Polevoy A. B., Garbutt J. C. and Janowsky D. S. Evidence of preference for a higher concentration sucrose solution in alcoholic and nonalcoholic men // Am. Jour. of Psychiatry. 1997. Vol. 154. P. 269-270.
  15. Kampov-Polevoy A. B., Tzoi M., Zvartau E. E., Neznanov N. G., Khalitov E. Sweet liking and family history of alcoholism in hospitalized alcoholic and non-alcoholic patients // Alcohol and Alcoholism. 2001. Vol. 36. № 2. P. 165-170.
  16. Kuzmin A. V., Semenova S. G., Ramsey N., Zvartau E. E., Van Ree J. Modulation of cocaine intravenous self-administration in drug naive animals by dihydropiridine calcium channel modulators // Eur. J. Neuropsychopharmacol. 1996. Vol. 295 (1) P. 19-25.
  17. Kuzmin A. V., Semenova S. G., Zvartau E. E., Van Ree J. Enhancement of morphine self-administration in drug naive, inbred strains of mice by acute emotional stress // Eur. J. Neuropsychopharmacol. 1996. Vol. 296 (1). P. 63-68.
  18. Overstreet D. H., Kampov-Polevoy A. B., Rezvani A. H. et al. Saccharin intake predicts ethanol intake in genetically heterogeneous rats as well as different rat strains // Alcohol: Clin. Exp. Res. 1993. Vol. 17. P. 366-369.
  19. Pekkanen L., Eriksson K. and Sihvonen M. L. Dietary induced changes in voluntary alcohol consumption and ethanol metabolism in rats // British Jour. of Nutrition. 1978. Vol. 40. P. 103-113.
  20. Stewart R. B., Russel R. N., Lumeng L., Li T.-K. and Murphy L. M. Consumption of sweet, salty, sour and bitter solutions by selectively bred alcohol-preferring and alcohol-nonpreferring lines of rats // Alcoholism: Clin. and Exp. Res. 1994. Vol. 21 (Suppl. 3). 16A.
  21. Yung L., Gordis E. and Holt J. Dietary choices and likelihood of abstinence in an out patient clinic // Drug and Alcohol Dependence. 1983. Vol. 12. P. 355-362.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2003 Eco-Vector


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 74760 от 29.12.2018 г.