Email this article Immunomodulating effect of Lyprinol in humans following vaccination with live influenza vaccine
- Authors: Naykhin A.N.1, Rekstin A.R.1, Donina S.A.1, Desheva J.A.1, Grigorieva E.P.1, Borland R.2, Rudenko L.G.1
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Affiliations:
- Research Institute of Experimental Medicine of the RAMS
- Royal Melbourne Institute of Technology University
- Issue: Vol 3, No 4 (2003)
- Pages: 60-65
- Section: Clinical medicine
- Published: 25.11.2003
- URL: https://journals.eco-vector.com/MAJ/article/view/693773
- ID: 693773
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Abstract
Live cold-adapted reassortant influenza vaccine (LAIV) have been used in Russia for many years to control influenza among children, adults and elderly. The data presented reveal the possibility of using food supplement - Lyprinol as immunomodulator of immune response in humans after vaccination with live influenza vaccine. It had been shown that Lyprinol possesses significant stimulating effect with a prolonged action on post-vaccination antibody and cell-mediated immune response to live influenza vaccine. Taking Lyprinol did not lead to any suppression of systemic or local immunity. No any clinical and allergic reactions while taking Lyprinol have been observed. Thus Lyprinol can be recommended as safe inducer of immune response to LAIV. Moreover, Lyprinol is prophylactic preparation in those with osteoarthritis, rheumatoid arthritis, asthma and number of gynecology and skin diseases. Especially Lyprinol is a potent for raising immune response to LAIV in elderly with age related immunodeficiency.
About the authors
A. N. Naykhin
Research Institute of Experimental Medicine of the RAMS
Author for correspondence.
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg, 197376
A. R. Rekstin
Research Institute of Experimental Medicine of the RAMS
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg, 197376
S. A. Donina
Research Institute of Experimental Medicine of the RAMS
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg, 197376
J. A. Desheva
Research Institute of Experimental Medicine of the RAMS
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg, 197376
E. P. Grigorieva
Research Institute of Experimental Medicine of the RAMS
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg, 197376
R. Borland
Royal Melbourne Institute of Technology University
Email: shabanov@mail.rcom.ru
Australia, Melbourne 3000
L. G. Rudenko
Research Institute of Experimental Medicine of the RAMS
Email: shabanov@mail.rcom.ru
Russian Federation, 197376, St. Petersburg
References
- Александрова Г. И., Климов А. И. Живая вакцина против гриппа. СПб.: Наука, 1994. 151 с.
- Бичурина М. А., Кубарь О. Н., Степанова Л. А., Никитина Л. Е. Использование мидийного гидролизата для защиты населения от гриппа и ОРВИ // Современные вопросы обеспечения санитарно-эпидемиологического благополучия населения: Материалы конференции. Вологда, 2002. С. 249-252.
- Найхин А. Н., Донина С. А., Кустикова Ю. Г.
- и др. Изучение в иммуноферментном анализе поствакцинального секреторного иммунитета к вирусам гриппа A и B с помощью разработанной моноклональной иммуноферментной тест-системы // Вопр. вирусол. 1997. Т. 42. № 6. С. 271-275.
- Найхин А. Н, Рекстин А. Р, Баранцева И. Б. и др. Иммунный ответ на живую гриппозную вакцину // Вести. РАМН. 2002. № 12. С. 24-28.
- Найхин А. Н., Рекстин А. Р., Кац Дж. и др. Пролиферативная активность лимфоцитов лиц пожилого возраста in vitro при раздельной и сочетанной иммунизации живой и инактивированной гриппозными вакцинами // Вопр. вирусол. 2000. № 2. С. 41-45.
- Фрейдлин И. С., Тотолян А. А. Клетки иммунной системы. СПб.: Наука, 2001. 390 с.
- Шварцман Я. С., Наихин А. Н., Исмагулов А. Т. Иммунология гриппа. Алма-Ата: Наука, 1985. 141 с.
- Bichurina M., Boikov J., Sovetova M. et al. The prevention and treatment of AVRI by means of mussels Hydrolisat // Abstracts of X-th international congress of Virology Jerusalem. 1996. P. 190.
- Chatterji A., Ansdri Z., Bichurina M. et al. Screening for antiviral activity in the Indian Green Mussel, Perna viridis (L) // J. Exp. Biol. (Australia). 2002. Vol. 23. № 5. P. 2023-2027.
- Chatterji A., Bichurina M., Sovetova M. et al. Indian marine bivalves: Potential source of antiviral drugs // J. Cur. Science. 2002. Vol. 82. № 10. P. 1279-1282.
- Duglas B. Lyprinol inhibits LTB4 production by human monocytes // Allerg. Immunol. 2000. Vol. 32. № 7. P. 284-289.
- Halpern G. Lyprinol. New York: Avery, 2001. 148 p.
- Halpern G. M. Anti-inflammatory effects of astabilized lipid extract of Perna Canaliculus (Lyprinol) // Allerg. Immunol. 2000. Vol. 32. № 7. P. 272-278.
- Harris W. C. Recent advances in human Nutrition and the science of pleasure // Newsletter. 1999. Vol. 2-3. P. 4-7.
- Lazar A., Wright P. F. Cell-mediated immune response of human lymphocytes to influenza А/USSR (H1N1) virus infection // Infect. Immunol. 1980. Vol. 27. № 3. P. 862-866.
- McGhee J. K., Kiyono H. New Respectives in vaccine development: mucosal immunity to infections // Infect. Agents Dis. 1993. Vol. 2. № 2. P. 55-73.
- Shiels I. A., Whitehouse M. W. Lyprinol: anti-inflammatory and uterine-relaxant activities in rats, with special reference to a model of dysmenorrhoea // Allerg. Immunol. 2000. Vol. 32. № 7. P. 279-283.
- Sincluir A. J., Murphy K. J., Li D. Marine lipids: Overview: New insights, and lipid composition of Lyprinol // Allerg. Immunol. 2000. Vol. 32. №7. P. 261-271.
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).