КОЖНЫЙ ЗУД КАК МАРКЕР ИММУННЫХ НАРУШЕНИЙ У БОЛЬНЫХ ПСОРИАЗОМ

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Introduction. Psoriasis (PS) is an immuno-associated disease and often is accompanied by pruritus [1, 2]. The interaction between the peripheral nervous system and the immune system is carried out through various types of skin nerve fibers that activate specific keratinocyte receptors [3]. The presence of pruritus in patients with PS may indicate violations of the immune system, which determines the relevance of the study. Based on the study of some indicators of cellular and humoral immunity, evaluate the features of immunoreactivity in patients with psoriasis with concomitant pruritus. Materials and methods. Patients with PS were examined (n = 97) and divided into 2 groups: group 1 - PS with pruritus (n = 73, mean age 40.0 ± 1.5 years), group 2 (comparison group) - PS without pruritus (n = 24, mean age 41.5 ± 2.7 years). The indicators of cellular immunity were determined by flow cytofluorimetry. The concentration of immunoglobulins, cytokines, circulating immune complexes (CIC) in serum was assessed by enzyme-linked immunosorbent assay. Statistica 6.0 was used for statistical analysis. Data are presented as medians, 25 and 75 quartiles (Me, Q25-Q75). Differences were considered statistically significant at p < 0.05. Results and discussion. As a result of the research, it was noted that the presence of pruritus in PS patients is associated with a severe clinical course of the disease. Thus, the average value of the PASI index (Psoriasis Area and Severity Index - index of PS severity) in group 1 was 17.3 (12.2; 20.1), in group 2 - 12.2 (7.8; 18.4), p1, 2 = 0.007. Complaints of pain in the joints in 41 (56.9%) cases are observed in group 1 and in 6 (25%) in group 2, p1, 2 = 0.006. During the study, it was determined that in the group of patients with PS with concomitant pruritus the phagocytic number is higher and the concentration of IgM in serum is lower in comparison with the group of patients with PS without pruritus: 5.0 (4.3; 5.5) and 4.0 (3.8; 5.4), p1, 2 = 0.04 and 0.6 g/l (0.4; 1.1) relative to 1.1 g/l (0.7; 1.3), p1, 2 = 0.03, respectively. An increase in the phagocytic number may indicate activation of the absorptive capacity of phagocytic neutrophils in PS with pruritus. A low serum IgM concentration may reflect a lack of humoral immunity as a result of a systemic psoriatic process in PS with concomitant pruritus. Previously conducted studies revealed differences in immunological parameters in patients with PS and psoriatic arthritis compared with the control group [4]. Conclusion. Studies have allowed to identify features of PS with concomitant pruritus: severe clinical course of the disease with damage to the musculoskeletal system, associated with selective deficiency of class M immunoglobulins and increased activity of phagocytic neutrophils. Therefore, the presence of pruritus in patients with PS is associated with a change in immunological parameters, which confirms the close relationship of the nervous and immune systems and may be one of the markers of the progression of psoriatic disease.

Об авторах

А А Барило

Научно-исследовательский институт медицинских проблем Севера - обособленное подразделение ФГБНУ «Федеральный исследовательский центр „Красноярский научный центр” Сибирского отделения РАН»

С В Смирнова

Научно-исследовательский институт медицинских проблем Севера - обособленное подразделение ФГБНУ «Федеральный исследовательский центр „Красноярский научный центр” Сибирского отделения РАН»

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