Влияние ксенона на выраженность болевого синдрома и адаптационный статус нейроонкологических и онкогинекологических больных

Полный текст

Background. The formation of the pain syndrome and malignant growth are associated with impaired neuroimmune relationships [2]. Xenon is reported to have neuroprotective and immunocorrective effects [3]. The aim of the study was to assess the association between an analgesic effect of xenon in cancer patients and changes in characteristics of adaptational reactions (AR), the development of which is caused by multi-level processes in the neuroendocrine and immune systems [1]. Material and methods. Indicators of the status were studied in 26 patients aged 39-70 years with solitary brain metastases (BM) from different primary tumors receiving radiotherapy (RT) after the removal of metastatic tumors. RT involved distant whole brain radiotherapy and a boost to the bed of removed metastasis 5 hours after the main RT. 10 of 26 patients received inhalations of a xenon-oxygen mixture twice a week during the whole RT cycle (RT+Xe). 30 patients with cervical cancer (CC), mean age 39.7 ± 1.3 years, were studied as well. All patients underwent radical hysterectomy under general anesthesia. 18 of 30 patients received a xenon therapy cycle (5 sessions) during the early postoperative period, without analgesics for at least 12 hours prior to the session. Other patients received standard therapy in the postoperative period. Patients with BM mainly reported headaches, and CC patients reported pain at the surgical site. The severity of pain in patients with BM was determined using the QLQ-C15 questionnaire. A 10-point graphical visual analogue scale (VAS) was used to assess the intensity of pain in patients with CC (0 - no pain, 10 - maximal pain). The adaptational status in all patients was evaluated by hematological parameters, first of all by the peripheral blood leukocyte count per 200 cells, with determination of the nature and tension of general nonspecific adaptational reactions of the body [1]. The tests were done before and after treatment. Statistical processing of results was performed using the nonparametric Wilcoxon-Mann-Whitney test and the fractional estimates. Results and discussion. The adaptational status of patients before treatment was characterized with the development of stress ARs (14-20% of cases), ARs of over-activation and tensioned anti-stress ARs of “low” (LRL) and “very low” (VLRL) reactivity levels. This indicated a significant decrease in the activity of the body’s defense systems and abnormal neuroimmune regulatory relationships in the development of malignant process in the brain and cervix. RT without xenon did not lead to a noticeable change in the state of patients with BM assessed by severity of pain (Table). Some improvement in the adaptational status was observed only in a quarter of patients who showed the development of the stress areactivity, significantly more favorable compared with stress and over-activation ARs [1] (Table). Xenon therapy after RT markedly improved all studied indicators. This was demonstrated by pain relief and improved adaptational status of patients - the development of stress areactivity or anti-stressor ARs of “moderate” reactivity levels (MRL) in 70% of cases (p < 0.05) (Table). Similar results were obtained in patients with CC. Surgery caused a predictable decline in the adaptational status of patients expressed by a significantly increased rates of stress ARs - from 14 to 75% of cases (p < 0.05). Xenon notably reduced negative effects of the surgery. The rate of anti-stressor ARs increased from 22 to 80% (p < 0.05), compared to the values on the first day after surgery. This was accompanied by a decreased analgesic use, from 56% (in the group without xenon) to 11% of cases (p < 0.05). Conclusions. The analgesic effect of xenon in neuro-oncological and gynecological patients is associated with an improvement in the characteristics of integral reactions, reflecting the state of neuroimmune processes and reducing of the damaging effect of a special antitumor treatment.

Об авторах

Н Н Попова

ФГБУ «Ростовский научно-исследовательский онкологический институт» Минздрава России

М С Зинькович

ФГБУ «Ростовский научно-исследовательский онкологический институт» Минздрава России

А И Шихлярова

ФГБУ «Ростовский научно-исследовательский онкологический институт» Минздрава России

Г В Жукова

ФГБУ «Ростовский научно-исследовательский онкологический институт» Минздрава России

Л Я Розенко

ФГБУ «Ростовский научно-исследовательский онкологический институт» Минздрава России

Т П Протасова

ФГБУ «Ростовский научно-исследовательский онкологический институт» Минздрава России

А С Гончарова

ФГБУ «Ростовский научно-исследовательский онкологический институт» Минздрава России

М И Брагина

ФГБУ «Ростовский научно-исследовательский онкологический институт» Минздрава России

Список литературы

Дополнительные файлы