VON WILLEBRAND FACTOR OF ENDOTHELIOCYTES OF BLOOD VESSELS AND ITS USE IN THE COURSE OF IMMUNOMORPHOLOGYCAL RESEARCHES



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Abstract

The most frequent problem of the surgical treatment of the phlebeurysm is the repatency of thrombuses. The main cell population that prevents the formation of thrombuses and contributes to their repatency is presented by endotheliocytes of intima of vessels. One of important directions of the contemporary immunomorphological angiology is determination of markers of the functional activity of the endothelium that has the high predictive validity in relation to the prediction of results of the surgical treatment. The possible expectant to be such a marker is the protein that is synthesized with endotheliocytes, it is called von Willebrand factor. In the present article data are generalized and analyzed that are available in the literature worldwide concerning the molecular organization and functions of von Willebrand factor, the comparison of different morphological ways of its detection in situ has been carried out. Based on the overview of literature and own data a conclusion has been drawn that the method of the confocal laser microscopy makes possible in course of the immunocytochemical marking of the von Willebrand factor to study its distribution in the cytoplasm of separate endotheliocytes as well as in the subendothelial area of the wall of the blood vessel. Data on the intracellular and extracellular accumulation of the von Willebrand factor are necessary for the correct evaluation of the functional state of the endothelial lepidic tissue.

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About the authors

D E Korzhevskii

Institute of Experimental Medicine

O V Kirik

Institute of Experimental Medicine

E G Sukhorukova

Institute of Experimental Medicine

O S Alekseeva

Institute of Experimental Medicine

E V Shaydakov

Institute of Experimental Medicine

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Copyright (c) 2017 Korzhevskii D.E., Kirik O.V., Sukhorukova E.G., Alekseeva O.S., Shaydakov E.V.

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